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首页> 外文期刊>Nuclear Medicine Communications >Optimized protocols in terms of equalizing the true and accidental coincidences of each bed position in static multiple bed position carbon-11 PET studies and a target single bed position study.
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Optimized protocols in terms of equalizing the true and accidental coincidences of each bed position in static multiple bed position carbon-11 PET studies and a target single bed position study.

机译：在均衡静态多床位Carbon-11 PET研究和目标单床位研究中每个床位的真实和偶然重合方面，优化了方案。

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摘要

Quantitative carbon-11 (11C) positron emission tomography (PET) is gaining more attention in oncological applications. In addition, it was discovered that accidental coincidences (randoms) can play an important role in studies such as partial volume effects correction without needing to use anatomical information. However, because of the short half-life of 11C, a homogeneous multiple bed position 11C image is hard to obtain. This study aimed to determine whether innovative pseudogating, optimized pseudogating and optimized double-up methods could match the true counts and randoms to each bed position and to a target single bed position study. A long cylindrical phantom filled with [11C]acetate was scanned by a dedicated PET scanner using six protocols: whole body, frame-duration-compensated whole body, double-up, optimized double-up, pseudogating, and optimized pseudogating. The differences between the protocols are in the initial activity, frame duration and frame number for each bed position. The parameters for pseudogating were determined according to the theory that true counts and randoms are proportional to the radioactivity and its square, respectively. The results show that the stated goals could only be achieved by pseudogating and optimized pseudogating. We conclude that pseudogating or optimized pseudogating must be applied for a critical quantitative study. However, optimized double-up and double-up methods are good alternatives for semi-quantitative and qualitative studies, respectively.
机译：定量碳11（11C）正电子发射断层扫描（PET）在肿瘤学应用中越来越受到关注。另外，已经发现偶然的巧合（随机）可以在不需要使用解剖信息的情况下在诸如部分体积效应校正之类的研究中发挥重要作用。然而，由于11C的半衰期短，所以难以获得均匀的多床位置11C图像。本研究旨在确定创新的假门，优化的假门和优化的双倍法是否可以将真实计数和随机数与每个床位和目标单床位研究相匹配。专用的PET扫描仪使用六种规程扫描填充了[11C]乙酸酯的长圆柱体模：全身，帧时长补偿的全身，双倍，优化双倍，假门和优化假门。协议之间的差异在于每个床位的初始活动，帧持续时间和帧号。根据真实计数和随机数分别与放射性及其平方成正比的理论确定用于伪门控的参数。结果表明，只能通过伪门控和优化伪门控来实现所述目标。我们得出的结论是，伪门或优化伪门必须用于关键的定量研究。但是，优化的加倍法和加倍法分别是半定量和定性研究的良好选择。

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