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首页> 外文期刊>Nuclear Medicine Communications >Pulsed Doppler tissue imaging for the assessment of myocardial viability: comparison with 99mTc sestamibi perfusion imaging.
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Pulsed Doppler tissue imaging for the assessment of myocardial viability: comparison with 99mTc sestamibi perfusion imaging.

机译：脉冲多普勒组织成像用于评估心肌的生存能力：与99mTc西司他比灌注成像的比较。

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The aim of the present study was to examine whether Doppler tissue imaging demonstrated comparable diagnostic performance for the detection of viable myocardium compared to myocardial perfusion imaging with Tc hexakis-2-methoxyisobutylisonitrile (MIBI). We studied 30 patients with old myocardial infarction who underwent percutaneous transluminal coronary angioplasty (PTCA). Myocardial single photon emission computed tomography (SPECT) with Tc-MIBI and two-dimensional echocardiography were carried out within 7 days before PTCA. We measured regional Tc-MIBI uptake for each myocardial segment from SPECT and peak systolic velocity and a ratio of regional pre-ejection period to regional ejection time (PEP/ET) from pulsed Doppler tissue imaging. Biplane left ventriculography was performed before interventional procedures and repeated 3 months after PTCA. Myocardial viability was determined when wall motion was improved at least one grade after PTCA. The peak systolic velocity was positively correlated with regional Tc-MIBI uptake (R =0.59, P<0.01). The PEP/ET demonstrated inverse correlation with Tc-MIBI uptake ( R=-0.59, P<0.01). Peak systolic velocity of viable segments was higher than that of non-viable segments ( P<0.05). The PEP/ET was lower in viable segments than in non-viable segments ( P<0.05). Peak systolic velocity and PEP/ET demonstrated high diagnostic accuracy for detecting viable myocardium compared with Tc-MIBI perfusion imaging (80% and 79% vs 90%). These data indicate that measurements of regional peak systolic velocity and PEP/ET by Doppler tissue imaging are useful for evaluating myocardial viability quantitatively and provide helpful information for a clinical judgment in an interventional strategy.
机译：本研究的目的是检查与使用Tc六-2-甲氧基异丁基异腈（MIBI）进行的心肌灌注成像相比，多普勒组织成像是否表现出可比的诊断性能来检测存活的心肌。我们研究了30例行经皮腔内冠状动脉成形术（PTCA）的老年心肌梗塞患者。在PTCA前7天内进行了带有Tc-MIBI的心肌单光子发射计算机断层扫描（SPECT）和二维超声心动图。我们从SPECT测量了每个心肌节段的区域Tc-MIBI摄取量，并从脉冲多普勒组织成像中测量了峰值收缩期速度以及区域预喷射期与区域喷射时间（PEP / ET）的比率。在介入手术之前进行双翼左心室造影，并在PTCA之后重复3个月。在PTCA后至少1级改善壁运动时，确定了心肌的生存能力。峰值收缩速度与区域Tc-MIBI摄取呈正相关（R = 0.59，P <0.01）。 PEP / ET与Tc-MIBI摄取呈负相关（R = -0.59，P <0.01）。可行节段的峰值收缩速度高于非可行节段（P <0.05）。可行段PEP / ET低于不可行段（P <0.05）。与Tc-MIBI灌注成像相比，峰值收缩速度和PEP / ET表现出较高的诊断准确性，可检测出存活的心肌（80％和79％vs 90％）。这些数据表明，通过多普勒组织成像对区域峰值收缩期速度和PEP / ET的测量可用于定量评估心肌生存力，并为介入策略中的临床判断提供有用的信息。

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