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Genetic and genomic insights into the molecular basis of atherosclerosis.

机译：动脉粥样硬化分子基础的遗传学和基因组学见解。

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Atherosclerosis is a complex disease involving genetic and environmental risk factors, acting on their own or in synergy. Within the general population, polymorphisms within genes in lipid metabolism, inflammation, and thrombogenesis are probably responsible for the wide range of susceptibility to myocardial infarction, a fatal consequence of atherosclerosis. Genetic linkage studies have been carried out in both humans and mouse models to identify these polymorphisms. Approximately 40 quantitative trait loci for atherosclerotic disease have been found in humans, and approximately 30 in mice. Recently, genome-wide association studies have been used to identify atherosclerosis-susceptibility polymorphisms. Although discovering new atherosclerosis genes through these approaches remains challenging, the pace at which these polymorphisms are being found is accelerating due to rapidly improving bioinformatics resources and biotechnologies. The outcome of these efforts will not only unveil the molecular basisof atherosclerosis but also facilitate the discovery of drug targets and individualized medication against the disease.
机译：动脉粥样硬化是一种复杂的疾病，涉及遗传和环境风险因素，它们自身或协同作用。在一般人群中，脂质代谢，炎症和血栓形成的基因内的多态性可能是导致广泛的心肌梗死敏感性的原因，这是动脉粥样硬化的致命后果。已经在人和小鼠模型中进行了遗传连锁研究，以鉴定这些多态性。在人类中发现了约40个用于动脉粥样硬化疾病的定量性状基因座，在小鼠中发现了约30个。近来，全基因组关联研究已用于鉴定动脉粥样硬化易感性多态性。尽管通过这些方法发现新的动脉粥样硬化基因仍然具有挑战性，但是由于生物信息学资源和生物技术的迅速改善，发现这些多态性的步伐正在加快。这些努力的结果不仅将揭示动脉粥样硬化的分子基础，而且还将促进针对该疾病的药物靶标和个性化药物的发现。

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