• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Cell metabolism >Disruption of BCATm in mice leads to increased energy expenditure associated with the activation of a futile protein turnover cycle.
【24h】

Disruption of BCATm in mice leads to increased energy expenditure associated with the activation of a futile protein turnover cycle.

机译：小鼠中BCATm的破坏导致与无效蛋白质更新周期的激活相关的能量消耗增加。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Leucine is recognized as a nutrient signal; however, the long-term in vivo consequences of leucine signaling and the role of branched-chain amino acid (BCAA) metabolism in this signaling remain unclear. To investigate these questions, we disrupted the BCATm gene, which encodes the enzyme catalyzing the first step in peripheral BCAA metabolism. BCATm(-/-) mice exhibited elevated plasma BCAAs and decreased adiposity and body weight, despite eating more food, along with increased energy expenditure, remarkable improvements in glucose and insulin tolerance, and protection from diet-induced obesity. The increased energy expenditure did not seem to be due to altered locomotor activity, uncoupling proteins, sympathetic activity, or thyroid hormones but was strongly associated with food consumption and an active futile cycle of increased protein degradation and synthesis. These observations suggest that elevated BCAAs and/or loss of BCAA catabolism in peripheral tissues play an important role in regulating insulin sensitivity and energy expenditure.
机译：亮氨酸被认为是一种营养信号。然而，尚不清楚亮氨酸信号传导的长期体内后果以及支链氨基酸（BCAA）代谢在该信号传导中的作用。为了研究这些问题，我们破坏了BCATm基因，该基因编码催化外围BCAA代谢第一步的酶。 BCATm（-/-）小鼠尽管吃了更多的食物，但血浆BCAA升高，脂肪和体重下降，并且能量消耗增加，葡萄糖和胰岛素耐受性得到显着改善，并且免受饮食诱发的肥胖的影响。能量消耗的增加似乎不是由于运动能力的改变，蛋白的解偶联，交感神经活性或甲状腺激素的改变，但与食物消耗以及增加的蛋白质降解和合成的无效活动密切相关。这些观察结果表明，周围组织中BCAA的升高和/或BCAA分解代谢的丧失在调节胰岛素敏感性和能量消耗方面起着重要作用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号