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首页> 外文期刊>Cell metabolism >The transcriptional coactivator PGC-1beta drives the formation of oxidative type IIX fibers in skeletal muscle.
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The transcriptional coactivator PGC-1beta drives the formation of oxidative type IIX fibers in skeletal muscle.

机译：转录共激活因子PGC-1beta驱动骨骼肌中氧化型IIX纤维的形成。

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摘要

Skeletal muscle must perform different kinds of work, and distinct fiber types have evolved to accommodate these. Previous work had shown that the transcriptional coactivator PGC-1alpha drives the formation of type I and IIA muscle fibers, which are "slow-twitch" and highly oxidative. We show here that transgenic expression of PGC-1beta, a coactivator functionally similar to but distinct from PGC-1alpha, causes a marked induction of IIX fibers, which are oxidative but have "fast-twitch" biophysical properties. PGC-1beta coactivates the MEF2 family of transcription factors to stimulate the type IIX myosin heavy chain (MHC) promoter. PGC-1beta transgenic muscle fibers are rich in mitochondria and are highly oxidative, at least in part due to coactivation by PGC-1beta of ERRalpha and PPARalpha. Consequently, these transgenic animals can run for longer and at higher work loads than wild-type animals. Together, these data indicate that PGC-1beta drives the formation of highly oxidative fibers containing type IIX MHC.
机译：骨骼肌必须执行不同种类的工作，并且已经开发出不同的纤维类型来适应这些工作。先前的研究表明，转录共激活因子PGC-1alpha可以驱动I型和IIA型肌肉纤维的形成，它们是“缓慢抽搐”且具有高氧化性。我们在这里显示PGC-1beta，功能上类似于但不同于PGC-1alpha的共激活因子PGC-1beta的转基因表达引起IIX纤维的明显诱导，该纤维具有氧化性，但具有“快速抽搐”的生物物理特性。 PGC-1beta共激活MEF2家族的转录因子，以刺激IIX型肌球蛋白重链（MHC）启动子。 PGC-1beta转基因肌肉纤维富含线粒体并且高度氧化，至少部分是由于ERRalpha和PPARalpha的PGC-1beta共同激活。因此，这些转基因动物比野生型动物可以运行更长的时间和更高的工作量。这些数据加在一起表明PGC-1beta推动了含有IIX MHC类型的高氧化性纤维的形成。

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