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首页> 外文期刊>Cell metabolism >SIRT1 improves insulin sensitivity under insulin-resistant conditions by repressing PTP1B.
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SIRT1 improves insulin sensitivity under insulin-resistant conditions by repressing PTP1B.

机译：SIRT1通过抑制PTP1B改善了胰岛素抵抗条件下的胰岛素敏感性。

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Insulin resistance is often characterized as the most critical factor contributing to the development of type 2 diabetes. SIRT1 has been reported to be involved in the processes of glucose metabolism and insulin secretion. However, whether SIRT1 is directly involved in insulin sensitivity is still largely unknown. Here we show that SIRT1 is downregulated in insulin-resistant cells and tissues and that knockdown or inhibition of SIRT1 induces insulin resistance. Furthermore, increased expression of SIRT1 improved insulin sensitivity, especially under insulin-resistant conditions. Similarly, resveratrol, a SIRT1 activator, enhanced insulin sensitivity in vitro in a SIRT1-dependent manner and attenuated high-fat-diet-induced insulin resistance in vivo at a dose of 2.5 mg/kg/day. Further studies demonstrated that the effect of SIRT1 on insulin resistance is mediated by repressing PTP1B transcription at the chromatin level. Taken together, the finding that SIRT1 improves insulin sensitivity has implicationstoward resolving insulin resistance and type 2 diabetes.
机译：胰岛素抵抗通常被认为是导致2型糖尿病发展的最关键因素。据报道SIRT1参与葡萄糖代谢和胰岛素分泌过程。但是，SIRT1是否直接参与胰岛素敏感性仍不清楚。在这里，我们显示SIRT1在胰岛素抵抗细胞和组织中被下调，而SIRT1的抑制或诱导诱导胰岛素抵抗。此外，SIRT1表达的增加改善了胰岛素敏感性，尤其是在胰岛素抵抗的情况下。同样，白藜芦醇（SIRT1激活剂）以SIRT1依赖性方式增强了体外胰岛素敏感性，并以2.5 mg / kg / day的剂量减弱了体内高脂饮食诱导的胰岛素抵抗。进一步的研究表明，SIRT1对胰岛素抵抗的作用是通过在染色质水平上抑制PTP1B转录来介导的。综上所述，SIRT1改善胰岛素敏感性的发现对解决胰岛素抵抗和2型糖尿病具有重要意义。

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