• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Cell metabolism >Thiazolidinediones Enhance Sodium-Coupled Bicarbonate Absorption from Renal Proximal Tubules via PPARgamma-Dependent Nongenomic Signaling.
【24h】

Thiazolidinediones Enhance Sodium-Coupled Bicarbonate Absorption from Renal Proximal Tubules via PPARgamma-Dependent Nongenomic Signaling.

机译：噻唑烷二酮可通过PPARγ依赖性非基因组信号增强肾近端小管对碳酸钠的吸收。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Thiazolidinediones (TZDs) improve insulin resistance by activating a nuclear hormone receptor, peroxisome proliferator-activated receptor gamma (PPARgamma). However, the use of TZDs is associated with plasma volume expansion through a mechanism that remains to be clarified. Here we showed that TZDs rapidly stimulate sodium-coupled bicarbonate absorption from the renal proximal tubule in vitro and in vivo. TZD-induced transport stimulation is dependent on PPARgamma-Src-EGFR-ERK and observed in rat, rabbit and human, but not in mouse proximal tubules where Src-EGFR is constitutively activated. The existence of PPARgamma-Src-dependent nongenomic signaling, which requires the ligand-binding ability, but not the transcriptional activity of PPARgamma, is confirmed in mouse embryonic fibroblast cells. The enhancement of the association between PPARgamma and Src by TZDs supports an indispensable role of Src in this signaling. These results suggest that the PPARgamma-dependent nongenomic stimulation of renal proximal transport is also involved in TZD-induced volume expansion.
机译：噻唑烷二酮（TZD）通过激活核激素受体，过氧化物酶体增殖物激活的受体γ（PPARgamma）来改善胰岛素抵抗。但是，TZD的使用与血浆体积的扩展有关，其机制尚待阐明。在这里，我们表明TZD在体外和体内均能迅速刺激肾近端小管的钠耦合碳酸氢盐吸收。 TZD诱导的运输刺激取决于PPARgamma-Src-EGFR-ERK，并且在大鼠，兔和人中观察到，但在Src-EGFR被组成性激活的小鼠近端小管中则未观察到。在小鼠胚胎成纤维细胞中已证实存在PPARgamma-Src依赖性非基因组信号，该信号需要配体结合能力，但不需要PPARgamma的转录活性。 TZD增强了PPARgamma和Src之间的关联，支持了Src在此信号中的必不可少的作用。这些结果表明，肾脏近端转运的PPARγ依赖性非基因组刺激也与TZD诱导的体积扩张有关。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号