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首页> 外文期刊>Cell metabolism >Amino Acid-Dependent Activation of Liver Estrogen Receptor Alpha Integrates Metabolic and Reproductive Functions via IGF-1.
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Amino Acid-Dependent Activation of Liver Estrogen Receptor Alpha Integrates Metabolic and Reproductive Functions via IGF-1.

机译：肝脏雌激素受体α的氨基酸依赖性激活通过IGF-1整合了代谢和生殖功能。

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Throughout evolution, organisms have devised strategies to limit fertility in case of prolonged starvation. In mammals, the liver plays a central role in the orchestration of mechanisms allowing for the maintenance of energy homeostasis. We here demonstrate that dietary amino acids regulate the transcriptional activity of hepatic estrogen receptor alpha (ERalpha) through an mTOR-dependent mechanism. As a result of ERalpha activation, hepatic IGF-1 mRNA and blood IGF-1 are increased. Conversely, calorie restriction or selective ablation of ERalpha in the liver decrease blood IGF-1 to levels inadequate for the correct proliferation of the lumen epithelium in the uterus and the progression of the estrous cycle. We propose that the liver acts as critical mediator of energetic and reproductive functions responsible for the blockade of the estrous cycle in case of protein scarcity. Our findings may provide novel insights to understand the cause of selected forms of infertility and metabolic alterations in women after menopause.
机译：在整个进化过程中，生物体已制定出策略来限制长期饥饿的生育能力。在哺乳动物中，肝脏在协调维持能量动态平衡的机制中起着核心作用。我们在这里证明饮食氨基酸通过mTOR依赖性机制调节肝雌激素受体α（ERalpha）的转录活性。 ERalpha激活的结果是，肝脏IGF-1 mRNA和血液IGF-1升高。相反，肝脏中的卡路里限制或ERα的选择性消融将血液IGF-1降低到不足以使子宫内腔上皮正确增殖和发情周期的进展。我们建议肝脏在蛋白质缺乏的情况下充当发情周期阻断的能量和生殖功能的关键介质。我们的发现可能提供新颖的见解，以了解更年期后妇女某些形式的不育和代谢改变的原因。

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