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首页> 外文期刊>Cell metabolism >Insulin/IGF-1 receptor signaling enhances biosynthetic activity and fat mobilization in the initial phase of starvation in adult male C. elegans.
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Insulin/IGF-1 receptor signaling enhances biosynthetic activity and fat mobilization in the initial phase of starvation in adult male C. elegans.

机译：在成年雄性秀丽隐杆线虫饥饿的初期，胰岛素/ IGF-1受体信号传导增强了生物合成活性和脂肪动员。

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摘要

Upon nutrient deprivation, cells are thought to suppress biosynthesis but activate catabolic pathways to provide alternative energy sources and nutrients. However, here we provide evidence that in adult male C. elegans, both biosynthesis and degradation activities, including ribosome biogenesis and turnover, are enhanced during early starvation and appear to depend on the availability of intestinal lipid stores. Upon depletion of the intestinal lipids, further food deprivation results in a significant reduction in metabolic activity in the starved male worms. Our data show that adult C. elegans exhibits a two-phase metabolic response to starvation stress: an initial phase with enhanced metabolic activity that rapidly exhausts the lipid stores, followed by a phase with low metabolic activity, which outlasts the life of fed control worms. DAF-2 insulin/IGF-1 receptor signaling to the RAS pathway is required for the starvation-induced ribosome biogenesis and rapid lipid depletion in the initial phase of starvation.
机译：营养物质被剥夺后，细胞被认为抑制生物合成，但激活分解代谢途径以提供替代能源和营养物质。但是，这里我们提供的证据表明，在成年雄性秀丽隐杆线虫中，其生物合成和降解活性（包括核糖体的生物发生和周转率）在饥饿初期都得到增强，并且似乎取决于肠道脂质存储的可用性。肠脂质耗尽后，进一步的食物缺乏会导致饥饿的雄性蠕虫的代谢活性显着降低。我们的数据表明，成年秀丽隐杆线虫对饥饿压力表现出两阶段的代谢反应：具有增强的代谢活性的初始阶段会迅速耗尽脂质存储，其次是具有低代谢活性的阶段，这会延长饲喂控制蠕虫的寿命。饥饿诱导的核糖体生物发生和饥饿初期的快速脂质消耗需要DAF-2胰岛素/ IGF-1受体向RAS途径的信号传导。

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