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The ACTN3 R577X polymorphism affects the lipid profile and the prognosis of nutritional intervention in HIV-positive patients

机译：ACTN3 R577X基因多态性影响HIV阳性患者的血脂谱和营养干预预后

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The hypothesis of the present study is that the polymorphisms in the APOC3, CEPT, ACE, and ACTN3 genes can affect the outcome of nutritional intervention and the plasma lipid profile of HIV+ patients. To test the hypothesis, genetic material was collected from buccal cells, and serum was collected for biochemical analysis. Sixty-five patients were analyzed. The incorporation of protease inhibitor (PI) was more frequent in women (77% vs 33% in men). Nutritional intervention improved anthropometric parameters independent of the genotype. Patients with the RR genotype for the ACTN3 R577X polymorphism had lower glycemia (RR = 95.4 +/- 6.5 mg/dL, RX = 102.6 +/- 10.6 mg/dL, XX = 110.1 +/- 16.3 mg/dL; P = .03) and a greater reduction in low-density lipoproteins (LDL) after intervention (LDL: RR = -23.7 +/- 15.8 mg/dL, RX = 1.32 +/- 5.13 mg/dL, XX = 30.21 +/- 24.4 mg/dL; P = .01). Patients using PI had a negative response to dietary intervention regarding the levels of high-density lipoprotein (-2.4 +/- 1.70 with PI, 2.56 +/- 1.60 mg/dL without PI; P = .02), very low density lipoprotein (0.84 +/- 2.73 with IP, -5.46 +/- 3.37 mg/dL without PI; P = .03), and triglycerides (1.79 +/- 13.22 with PI, -34.00 +/- 17.67 mg/dL without PI; P = .052). This response was also independent of the genotype (P > 0.05) and suggested the need for oral lipid-lowering drugs in all HIV+ patients using PI. Our results indicate that the ACTN3 R577X polymorphism is a good predictor of both the lipid profile and the prognosis of nutritional intervention in reducing LDL in HIV+ patients. (C) 2016 Elsevier Inc. All rights reserved.
机译：本研究的假设是，APOC3，CEPT，ACE和ACTN3基因的多态性会影响营养干预的结果和HIV +患者的血脂水平。为了检验假设，从颊细胞中收集遗传物质，并收集血清进行生化分析。分析了65例患者。女性中蛋白酶抑制剂（PI）的掺入率更高（男性为77％，男性为33％）。营养干预改善了人体测量参数，而与基因型无关。具有ACTN3 R577X多态性RR基因型的患者的血糖较低（RR = 95.4 +/- 6.5 mg / dL，RX = 102.6 +/- 10.6 mg / dL，XX = 110.1 +/- 16.3 mg / dL; P =。 03）和干预后低密度脂蛋白（LDL）的更大降低（LDL：RR = -23.7 +/- 15.8 mg / dL，RX = 1.32 +/- 5.13 mg / dL，XX = 30.21 +/- 24.4 mg / dL; P = 0.01）。使用PI的患者在饮食干预方面对高密度脂蛋白（PI时为-2.4 +/- 1.70，没有PI时为2.56 +/- 1.60 mg / dL; P = .02），极低密度脂蛋白（P = .02）的反应为阴性IP为0.84 +/- 2.73，无PI时为-5.46 +/- 3.37 mg / dL; P = .03）和甘油三酸酯（有PI时为1.79 +/- 13.22，无PI时为-34.00 +/- 17.67 mg / dL; P = .052）。该反应也与基因型无关（P> 0.05），并提示所有使用PI的HIV +患者都需要口服降脂药。我们的结果表明，ACTN3 R577X基因多态性可以很好地预测脂质谱和营养干预在降低HIV +患者中LDL方面的预后。 （C）2016 Elsevier Inc.保留所有权利。

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