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首页> 外文期刊>Nutrition Research >Vitamin E supplementation protects erythrocyte membranes from oxidative stress in healthy Chinese middle-aged and elderly people.
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Vitamin E supplementation protects erythrocyte membranes from oxidative stress in healthy Chinese middle-aged and elderly people.

机译：补充维生素E可保护健康的中国中老年人和老年人的红细胞膜免受氧化应激。

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Elderly people are subject to higher levels of oxidative stress than are young people. Vitamin E, as a powerful antioxidant residing mainly in biomembranes, may provide effective protection against oxidative membrane damage and resultant age-related deterioration, especially in the elderly. We hypothesized that appropriate levels of vitamin E supplementation would protect erythrocyte membranes from oxidative stress and thus improve membrane fluidity in healthy middle-aged and elderly people. To test this, we conducted a 4-month double-blind, randomized trial in which 180 healthy subjects (55-70 years old) were randomly divided into 4 groups: group C (control), and 3 treatment groups in which daily doses of 100 mg (VE1), 200 mg (VE2), and 300 mg (VE3) dl- alpha-tocopheryl acetate were administered. We measured plasma alpha-tocopherol concentration, malondialdehyde, and superoxide dismutase levels, erythrocyte hemolysis, and erythrocyte membrane fluidity at the beginning and end of the trial. After 4 months supplementation, plasma alpha-tocopherol concentrations in the 3 treatment groups had increased by 71%, 78%, and 95%, respectively (all P < .01), and significant decreases in plasma malondialdehyde concentrations were observed in these groups (all P < .05). Erythrocyte hemolysis was decreased by 20% to 38% after vitamin E supplementation (all P < .05), and in addition, groups VE2 and VE3 showed dramatic improvements in erythrocyte membrane fluidity (P < .01). Surprisingly, superoxide dismutase activity also decreased significantly in the treatment groups (all P < .05). In summary, vitamin E supplementation apparently alleviates oxidative stress in healthy middle-aged to elderly people, at least in part by improving erythrocyte membrane fluidity and reducing erythrocyte hemolysis
机译：老年人比年轻人承受更高水平的氧化应激。维生素E是主要存在于生物膜中的一种强大的抗氧化剂，可以有效抵抗氧化膜损伤和由此引起的与年龄有关的退化，特别是在老年人中。我们假设适当水平的维生素E补充将保护红细胞膜免受氧化应激，从而改善健康的中老年人的膜流动性。为了测试这一点，我们进行了为期4个月的双盲随机试验，其中将180名健康受试者（55-70岁）随机分为4组：C组（对照组）和3个治疗组，每天服用分别给予100 mg（VE1），200 mg（VE2）和300 mg（VE3）的dl-α-生育酚乙酸酯。在试验的开始和结束时，我们测量了血浆α-生育酚浓度，丙二醛和超氧化物歧化酶水平，红细胞溶血和红细胞膜流动性。补充4个月后，3个治疗组的血浆α-生育酚浓度分别增加了71％，78％和95％（所有 P <.01），并且血浆丙二醛水平显着下降在这些组中观察到浓度（所有 P <.05）。补充维生素E后，红细胞溶血减少了20％至38％（所有 P <.05），此外，VE2和VE3组显示出红细胞膜流动性的显着改善（ P < / i> <.01）。令人惊讶的是，在治疗组中，超氧化物歧化酶活性也显着降低（所有 P <.05）。总而言之，补充维生素E显然可以减轻健康的中老年人的氧化应激，至少部分是通过改善红细胞膜的流动性和减少红细胞的溶血

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