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首页> 外文期刊>Nutrition, metabolism, and cardiovascular diseases: NMCD >Cardiac lipids and antioxidant status in high fructose rats and the effect of alpha-lipoic acid.
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Cardiac lipids and antioxidant status in high fructose rats and the effect of alpha-lipoic acid.

机译：高果糖大鼠的心脏脂质和抗氧化状态以及α-硫辛酸的影响。

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BACKGROUND AND AIMS: The development of insulin resistance has been shown to be an early step in the development of cardiovascular diseases in diabetic patients. Oxidative stress may be important in the development of coronary artery disease. Fructose loaded rats, which show the characteristic features of insulin resistance, also display an imbalance between the peroxidation process and the antioxidant system. Alpha-lipoic acid (LA)--a co-enzyme--is known for its potent antioxidant effects. The present study examined whether LA mitigates fructose-induced oxidative stress in heart tissue. METHODS AND RESULTS: Male Wistar rats with a body weight of 150-170g were divided into 4 groups of 6 rats each. Control rats received a control diet containing starch and water ad libitum. Fructose rats received a fructose-enriched diet (>60% of total calories). Fructose + LA rats received a fructose diet and alpha-lipoic acid (35mg/kg b.w i.p.). Control + LA rats received control diet and alpha-lipoic acid. After the 20-day treatment period, we assessed the insulin sensitivity index in terms of HOMA. The levels of lipid peroxidation markers and the enzymatic and non-enzymatic antioxidant status in the heart tissue were measured. Plasma and heart tissue lipids were also analysed. Fructose rats showed decreased insulin sensitivity as reflected by high values of HOMA, increased peroxidation, impaired antioxidant status and lipid abnormalities in the cardiac tissue. These abnormalities were attenuated and the antioxidant levels were enhanced by LA. The reduction in HOMA values suggests LA improves insulin sensitivity. CONCLUSIONS: Improvement of insulin sensitivity and enhancement of cardiac antioxidant status suggest that LA may be useful as a cardioprotective agent in insulin-resistant states.
机译：背景和目的：胰岛素抵抗的发展已被证明是糖尿病患者心血管疾病发展的早期步骤。氧化应激可能在冠状动脉疾病的发展中很重要。载有果糖的大鼠具有胰岛素抵抗的特征，在过氧化过程和抗氧化剂系统之间也表现出不平衡。硫辛酸（LA）-一种辅酶-以其强大的抗氧化作用而闻名。本研究检查了洛杉矶是否减轻了果糖引起的心脏组织中的氧化应激。方法与结果：将体重150-170g的雄性Wistar大鼠分为4组，每组6只。对照大鼠随意接受含淀粉和水的对照饮食。果糖大鼠接受富含果糖的饮食（>总卡路里的60％）。果糖+ LA大鼠接受果糖饮食和α-硫辛酸（35 mg / kg b.w i.p.）。对照+ LA大鼠接受对照饮食和α-硫辛酸。在20天的治疗期后，我们根据HOMA评估了胰岛素敏感性指数。测量心脏组织中脂质过氧化标志物的水平以及酶和非酶抗氧化剂的状态。还分析了血浆和心脏组织脂质。果糖大鼠显示出胰岛素敏感性降低，这表现为高HOMA值，过氧化增加，抗氧化剂状态受损和心脏组织脂质异常。这些异常被LA减轻并且抗氧化剂水平提高。 HOMA值的降低表明LA改善了胰岛素敏感性。结论：胰岛素敏感性的改善和心脏抗氧化剂状态的改善表明LA可能在胰岛素抵抗状态下可用作心脏保护剂。

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