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Energy intake and exercise as determinants of brain health and vulnerability to injury and disease

机译:能量摄入和运动是大脑健康以及受伤和疾病易感性的决定因素

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摘要

Evolution favored individuals with superior cognitive and physical abilities under conditions of limited food sources, and brain function can therefore be optimized by intermittent dietary energy restriction (ER) and exercise. Such energetic challenges engage adaptive cellular stress-response signaling pathways in neurons involving neurotrophic factors, protein chaperones, DNA-repair proteins, autophagy, and mitochondrial biogenesis. By suppressing adaptive cellular stress responses, overeating and a sedentary lifestyle may increase the risk of Alzheimer's and Parkinson's diseases, stroke, and depression. Intense concerted efforts of governments, families, schools, and physicians will be required to successfully implement brain-healthy lifestyles that incorporate ER and exercise.
机译:进化有利于在有限食物来源条件下具有卓越认知和身体能力的个体,因此可以通过间歇性饮食能量限制(ER)和运动来优化大脑功能。这种充满活力的挑战涉及神经营养因子,蛋白质伴侣,DNA修复蛋白,自噬和线粒体生物发生的神经元中的自适应细胞应激反应信号通路。通过抑制适应性细胞应激反应,暴饮暴食和久坐的生活方式可能增加阿尔茨海默氏症和帕金森氏症,中风和抑郁症的风险。政府,家庭,学校和医生需要作出巨大的共同努力,才能成功地实现将ER和运动结合在一起的大脑健康的生活方式。

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