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首页> 外文期刊>Cell metabolism >Chronic sympathoexcitation through loss of vav3, a rac1 activator, results in divergent effects on metabolic syndrome and obesity depending on diet
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Chronic sympathoexcitation through loss of vav3, a rac1 activator, results in divergent effects on metabolic syndrome and obesity depending on diet

机译：通过丧失vac3（一种rac1激活剂）引起的慢性交感神经兴奋对代谢综合征和肥胖的影响因饮食而异

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The role of the sympathetic nervous system, stress, and hypertension in metabolic syndrome and obesity remains unclear. To clarify this issue, we utilized genetically engineered mice showing chronic sympathoexcitation and hypertension due to lack of Vav3, a Rac1 activator. Here, we report that these animals develop metabolic syndrome under chow diet. However, they show protection from metabolic syndrome and obesity under fatty diets. These effects are elicited by α1-adrenergic- and diet-dependent metabolic changes in liver and the α1/β3 adrenergic-mediated stimulation of brown adipocyte thermogenesis. These responses seem to be engaged by the local action of noradrenaline in target tissues rather than by long-range effects of adrenaline. By contrast, they are not triggered by low parasympathetic drive or the hypertensive state present in Vav3-deficient mice. These results indicate that the sympathetic system plays divergent roles in the etiology of metabolic diseases depending on food regimen, sympathoexcitation source, and disease stage.
机译：交感神经系统，压力和高血压在代谢综合征和肥胖中的作用尚不清楚。为了澄清这个问题，我们利用基因工程小鼠，由于缺乏Rac1激活剂Vav3而表现出慢性交感神经兴奋和高血压。在这里，我们报道这些动物在低脂饮食下发展为代谢综合征。但是，在脂肪饮食下，它们对代谢综合症和肥胖症具有保护作用。这些作用是由肝脏中α1-肾上腺素能和饮食依赖性的代谢变化以及α1/β3肾上腺素能介导的棕色脂肪细胞生热刺激引起的。这些反应似乎是去甲肾上腺素在靶组织中的局部作用，而不是肾上腺素的远距离作用。相比之下，它们不是由低副交感神经驱动或Vav3缺陷小鼠中存在的高血压状态触发的。这些结果表明，交感神经系统在新陈代谢疾病的病因学中起着不同的作用，具体取决于饮食方案，交感神经来源和疾病阶段。

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