Metformin - Acting through cyclic AMP as well as AMP?

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Metformin - Acting through cyclic AMP as well as AMP?

机译：二甲双胍-通过循环AMP和AMP起作用？

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Metformin, developed from an ancient herbal remedy, remains the front-line drug for treatment of type 2 diabetes. Several targets to account for its therapeutic effects have been proposed, but a recent paper suggests a novel mechanism in which it antagonizes the cyclic AMP-dependent effects of glucagon on hepatic glucose production.

机译：从古老的草药中开发出来的二甲双胍仍然是治疗2型糖尿病的一线药物。已经提出了几种解释其治疗作用的靶标，但是最近的论文提出了一种新的机制，其中它拮抗了胰高血糖素对肝葡萄糖产生的环AMP依赖性循环作用。

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《Cell metabolism》 |2013年第3期|共2页
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HardieD.G.;
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正文语种 eng
中图分类内分泌腺疾病及代谢病;
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1. Metformin - Acting through cyclic AMP as well as AMP? [J] . HardieD.G. Cell metabolism . 2013,第3期

机译：二甲双胍-通过循环AMP和AMP起作用？
2. Transcriptional induction of the human renin gene by cyclic AMP requires cyclic AMP response element-binding protein (CREB) and a factor binding a pituitary-specific trans-acting factor (Pit-1) motif [J] . Florence PINET, Josette PHILIPPE, Pierre CORVOL, The biochemical journal . 1996,第1期

机译：环状AMP对人肾素基因的转录诱导需要环状AMP反应元件结合蛋白（CREB）和一个与垂体特异性反式作用因子（Pit-1）基序结合的因子
3. Long acting beta 2-agonist's activation of cyclic AMP cannot halt ongoing mitogenic stimulation in airway smooth muscle cells [J] . Qi Ying, Fang Lei, Stolz Daiana, Pulmonary pharmacology & therapeutics . 2019,第期

机译：长效β2-激动剂的循环amp的激活不能停止呼吸道平滑肌细胞中的持续散发性刺激
4. The positive effect of metformin on reproduction is through its action on AMPK in GT1-7 cells to regulate KISS1R, and GNRH1 expression [C] . Jingyun Fu, Xuan Qu, Jun Zhong, International Conference on Biological Information and Biomedical Engineering . 2019

机译：二甲双胍对繁殖的积极作用是通过其对GT1-7细胞中的AMPK的作用来调节Kiss1R，以及GNRH1表达
5. Extracellular adenosine, AMP, cyclic AMP and ammonia: Sampling and analysis techniques. [D] . Patterson, Shawnna Lee. 2001

机译：细胞外腺苷，AMP，环状AMP和氨水：采样和分析技术。
6. Transcriptional induction of the human renin gene by cyclic AMP requires cyclic AMP response element-binding protein (CREB) and a factor binding a pituitary-specific trans-acting factor (Pit-1) motif. [O] . S Germain, T Konoshita, J Philippe, 1996

机译：环状AMP对人类肾素基因的转录诱导需要环状AMP反应元件结合蛋白（CREB）和一个与垂体特异性反式作用因子（Pit-1）结合的因子。
7. Metformin-Acting through Cyclic AMP as well as AMP? [O] . Hardie, D Grahame 2013

机译：通过循环AMP和AMP进行二甲双胍的作用？
8. Cyclic AMP and Cyclic GMP Response to Stress in Brain and Pituitary: Stress Elevates Pituitary Cyclic AMP. [R] . Kant, G. J., Meyerhoff, J. L., Bunnell, B. N., 1982

机译：循环amp和循环Gmp对脑和垂体应激的反应：应激升高垂体环amp。

Metformin - Acting through cyclic AMP as well as AMP?

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