...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Cell metabolism >Obesity, rather than diet, drives epigenomic alterations in colonic epithelium resembling cancer progression
【24h】

Obesity, rather than diet, drives epigenomic alterations in colonic epithelium resembling cancer progression

机译：肥胖而不是饮食驱动结肠上皮的表观基因组改变，类似于癌症的进展

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

While obesity represents one of several risk factors for colorectal cancer in humans, the mechanistic underpinnings of this association remain unresolved. Environmental stimuli, including diet, can alter the epigenetic landscape of DNA cis-regulatory elements affecting gene expression and phenotype. Here, we explored the impact of diet and obesity on gene expression and the enhancer landscape in murine colonic epithelium. Obesity led to the accumulation of histone modifications associated with active enhancers at genomic loci downstream of signaling pathways integral to the initiation and progression of colon cancer. Meanwhile, colon-specific enhancers lost the same histone mark, poising cells for loss of differentiation. These alterations reflect a transcriptional program with many features shared with the program driving colon cancer progression. The interrogation of enhancer alterations by diet in colonic epithelium provides insights into the biology underlying high-fat diet and obesity as risk factors for colon cancer.
机译：肥胖是人类结直肠癌的几种危险因素之一，但这种关联的机制基础仍未解决。环境刺激，包括饮食，可以改变影响基因表达和表型的DNA顺式调控元件的表观遗传环境。在这里，我们探讨了饮食和肥胖对鼠结肠上皮基因表达和增强子景观的影响。肥胖导致与活性增强子相关的组蛋白修饰的积累在结肠癌的发生和发展所必需的信号通路下游的基因组位点。同时，结肠特异的增强子失去了相同的组蛋白标记，使细胞失去分化。这些改变反映出转录程序，其具有与驱动结肠癌进展的程序共享的许多特征。通过饮食对结肠上皮中的增强剂改变进行询问，可以深入了解高脂饮食和肥胖作为结肠癌危险因素的生物学基础。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号