Effects of dexamethasone on immune dysfunction and ventilator-associated pneumonia in COVID-19 acute respiratory distress syndrome: an observational study

Martin Cour; Marie Simon; Laurent ArgaudGuillaume MonneretFabienne Venet

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Effects of dexamethasone on immune dysfunction and ventilator-associated pneumonia in COVID-19 acute respiratory distress syndrome: an observational study

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Dexamethasone improves survival of patients with COVID-19 acute respiratory distress syndrome, but might shorten the delay between the start of invasive mechanical ventilation and the occurrence of ventilator-associated pneumonia, suggesting possible worsening of COVID-19-induced immune dysfunction with this treatment. In a prospective observational study, we found that mechanically ventilated patients with COVID-19 treated with dexamethasone presented earlier ventilator-associated pneumonia, had significantly lower monocyte Human Leukocyte Antigen-DR expression and number of circulating CD4 + cells after ICU admission, than those not treated with corticoids.

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《journal of intensive care》 |2021年第1期|64-67|共4页
作者
Martin Cour; Marie Simon; Laurent ArgaudGuillaume MonneretFabienne Venet;
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作者单位

Hospices Civils de Lyon, Intensive Care Medicine, Service de Médecine Intensive-Réanimation, Hôpital Edouard Herriot, 5, Place d'Arsonval, F-69437, Lyon Cedex 03;

Faculté de médecine Lyon-Est, Université de Lyon, Université Claude Bernard Lyon 1;

Immunology Laboratory, Hospices Civils de Lyon, Edouard Herriot HospitalCentre International de Recherche en Infectiologie (CIRI), Inserm U1111, CNRS, UMR5308, Ecole Normale Supérieure de Lyon, Université Claude;

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正文语种英语
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CD4 + lymphocyte; Intensive care unit; Monocyte HLA-DR; Nosocomial infection; SARS-CoV-2;

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Effects of dexamethasone on immune dysfunction and ventilator-associated pneumonia in COVID-19 acute respiratory distress syndrome: an observational study

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