...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Cell metabolism >Glutamate is a positive autocrine signal for glucagon release.
【24h】

Glutamate is a positive autocrine signal for glucagon release.

机译：谷氨酸盐是胰高血糖素释放的阳性自分泌信号。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

An important feature of glucose homeostasis is the effective release of glucagon from the pancreatic alpha cell. The molecular mechanisms regulating glucagon secretion are still poorly understood. We now demonstrate that human alpha cells express ionotropic glutamate receptors (iGluRs) that are essential for glucagon release. A lowering in glucose concentration results in the release of glutamate from the alpha cell. Glutamate then acts on iGluRs of the AMPA/kainate type, resulting in membrane depolarization, opening of voltage-gated Ca(2+) channels, increase in cytoplasmic free Ca(2+) concentration, and enhanced glucagon release. In vivo blockade of iGluRs reduces glucagon secretion and exacerbates insulin-induced hypoglycemia in mice. Hence, the glutamate autocrine feedback loop endows the alpha cell with the ability to effectively potentiate its own secretory activity. This is a prerequisite to guarantee adequate glucagon release despite relatively modest changes in blood glucose concentration under physiological conditions.
机译：葡萄糖稳态的一个重要特征是胰高血糖素从胰腺α细胞的有效释放。调节胰高血糖素分泌的分子机制仍知之甚少。现在，我们证明了人类α细胞表达离子性谷氨酸受体（iGluRs），这对于胰高血糖素的释放至关重要。葡萄糖浓度的降低导致谷氨酸从α细胞释放。谷氨酸然后作用于AMPA /海藻酸酯类型的iGluRs，导致膜去极化，电压门控Ca（2+）通道的打开，细胞质游离Ca（2+）浓度的增加和胰高血糖素释放的增强。 iGluRs的体内阻断作用降低了小鼠体内胰高血糖素的分泌并加剧了胰岛素诱导的低血糖症。因此，谷氨酸自分泌反馈回路赋予α细胞有效增强其自身分泌活性的能力。尽管在生理条件下血糖浓度发生相对适度的变化，但这仍是保证足够的胰高血糖素释放的前提。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号