HDL, ABC transporters, and cholesterol efflux: implications for the treatment of atherosclerosis.

Tall AR; Yvan Charvet L; Terasaka N

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HDL, ABC transporters, and cholesterol efflux: implications for the treatment of atherosclerosis.

机译：HDL，ABC转运蛋白和胆固醇外流：对动脉粥样硬化的治疗意义。

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High-density lipoprotein (HDL) has been identified as a potential target in the treatment of atherosclerotic vascular disease. The failure of torcetrapib, an inhibitor of cholesteryl ester transfer protein (CETP) that markedly increased HDL levels in a clinical trial, has called into doubt the efficacy of HDL elevation. Recent analysis suggests that failure may have been caused by off-target toxicity and that HDL is functional and promotes regression of atherosclerosis. New studies highlight the central importance of the ATP-binding cassette (ABC) transporters ABCA1 and ABCG1 in reducing macrophage foam cell formation, inflammation, and atherosclerosis. A variety of approaches to increasing HDL may eventually be successful in treating atherosclerosis.

机译：高密度脂蛋白（HDL）已被确定为治疗动脉粥样硬化性血管疾病的潜在靶标。在临床试验中，胆固醇酯转移蛋白（CETP）抑制剂torcetrapib的失败显着提高了HDL水平，这使人们怀疑HDL升高的功效。最近的分析表明，衰竭可能是由脱靶毒性引起的，并且HDL具有功能并促进了动脉粥样硬化的消退。新研究强调了ATP结合盒（ABC）转运蛋白ABCA1和ABCG1在减少巨噬细胞泡沫细胞形成，炎症和动脉粥样硬化中的重要作用。各种增加HDL的方法最终可能会成功治疗动脉粥样硬化。

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《Cell metabolism》 |2008年第5期|共11页
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Tall AR; Yvan Charvet L; Terasaka N;
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正文语种 eng
中图分类细胞生物学;
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1. HDL, ABC transporters, and cholesterol efflux: implications for the treatment of atherosclerosis. [J] . Tall AR, Yvan Charvet L, Terasaka N Cell metabolism . 2008,第5期

机译：HDL，ABC转运蛋白和胆固醇外流：对动脉粥样硬化的治疗意义。
2. Role of HDL, ABCA1, and ABCG1 transporters in cholesterol efflux and immune responses. [J] . Yvan Charvet L, Wang N, Tall AR Arteriosclerosis, thrombosis, and vascular biology . 2010,第2期

机译：HDL，ABCA1和ABCG1转运蛋白在胆固醇外排和免疫反应中的作用。
3. Small HDL Promotes Cholesterol Efflux by the ABCA1 Pathway in Macrophages Implications for Therapies Targeted to HDL [J] . Heinecke Jay W. Circulation research: a journal of the American Heart Association . 2015,第7期

机译：小型HDL通过ABCA1通路促进巨噬细胞对HDL靶向疗法的胆固醇外流。
4. Pharmaceutical Surfactants Interact Differently with the Human Efflux Transporters ABCB1 and ABCC2 [C] . Annual meeting exposition of the Controlled Release Society . 2009

机译：药物表面活性剂与人流速转运蛋白ABCB1和ABCC2相互作用
5. In vitro and in vivo regulation of pro-inflammatory cytokines and drug efflux transporters by signal transduction pathways in glial cells: implications in HIV-1 neuropathogenesis and its treatment. [D] . Ashraf, Tamima. 2015

机译：通过神经胶质细胞中的信号转导途径对促炎性细胞因子和药物外排转运蛋白的体外和体内调节：对HIV-1神经发病机制及其治疗的影响。
6. The role of HDL ABCA1 and ABCG1 transporters in cholesterol efflux and immune responses [O] . Laurent Yvan-Charvet, Nan Wang, Alan R. Tall -1

机译：HDLaBCa1和aBCG1转运体胆固醇流出和免疫反应中的作用
7. HDL, ABC Transporters, and Cholesterol Efflux: Implications for the Treatment of Atherosclerosis [O] . Tall Alan R., Yvan-Charvet Laurent, Terasaka Naoki, 2008

机译：HDL，ABC转运蛋白和胆固醇外流：对动脉粥样硬化的治疗意义。
8. Rethinking Drug Treatment Approaches in ALS by Targeting ABC Efflux Transporters. [R] . Pasinelli, P., Jacob, D. 2014

机译：通过靶向aBC外排转运蛋白重新思考aLs中的药物治疗方法。

HDL, ABC transporters, and cholesterol efflux: implications for the treatment of atherosclerosis.

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