Modifying Mitochondrial tRNAs: Delivering What the Cell Needs

Horvath Rita; Chinnery Patrick F.

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Modifying Mitochondrial tRNAs: Delivering What the Cell Needs

机译：修改线粒体tRNA：提供细胞所需的物质

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Protein synthesis is critically dependent on transfer (t)-RNAs, but the factors regulating tRNA function are poorly understood. In this issue of Cell Metabolism, Wei et al. (2015) show that Cdk5 regulatory subunit-associated protein-like-1 synchronizes mitochondrial and cytosolic translation in response to external stress, providing key insight into the pathogenesis of a common inherited mitochondrial disease.

机译：蛋白质合成关键取决于转移（t）-RNA，但调节tRNA功能的因素知之甚少。在本期《细胞代谢》中，Wei等人。（2015）表明Cdk5调节亚基相关蛋白样1响应外部压力同步线粒体和胞质的翻译，提供了一种常见的遗传线粒体疾病的发病机理的关键见解。

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《Cell metabolism》 |2015年第3期|共2页
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Horvath Rita; Chinnery Patrick F.;
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中图分类内分泌腺疾病及代谢病;
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1. Modifying Mitochondrial tRNAs: Delivering What the Cell Needs [J] . Horvath Rita, Chinnery Patrick F. Cell metabolism . 2015,第3期

机译：修改线粒体tRNA：提供细胞所需的物质
2. Mitochondrial import of a yeast cytoplasmic tRNALys: possible roles of aminoacylation and modified nucleosides in subcellular partitioning [J] . Entelis Nina S., Krasheninnikov Igor A., Martin Robert P., FEBS Letters . 1996,第1期

机译：线粒体导入酵母胞质tRNALys：氨基酰化和修饰的核苷在亚细胞分配中的可能作用
3. Mitochondrial ND5 T12338C, tRNA(Cys) T5802C, and tRNA(Thr) G15927A variants may have a modifying role in the phenotypic manifestation of deafness-associated 12S rRNA A1555G mutation in three Han Chinese pedigrees. [J] . Chen B, Sun D, Yang L, American journal of medical genetics, Part A . 2008,第10期

机译：线粒体ND5 T12338C，tRNA（Cys）T5802C和tRNA（Thr）G15927A变体在三个汉族谱系中与耳聋相关的12S rRNA A1555G突变的表型表现中可能具有修饰作用。
4. Direct incorporation of taurine into novel modified uridines at anticodon wobble position of human mitochondrial tRNAs [C] . 19th tRNA workshop tRNA 2002"" . 2002

机译：在人线粒体tRNA的反密码子摆动位置将牛磺酸直接掺入新型修饰的尿苷中
5. Enhanced Proangiogenic Activity of Endothelial Cells in Response to Polyglutamate Domain-Modified QK Peptides Delivered on Bone Grafting Materials [D] . Pensa, Nicholas Weldon. 2019

机译：响应于骨嫁接材料递送的聚谷氨酰胺结构域改性QK肽增强了内皮细胞的常致细胞活性
6. The isolated carboxy-terminal domain of human mitochondrial leucyl-tRNA synthetase rescues the pathological phenotype of mitochondrial tRNA mutations in human cells [O] . Elena Perli, Carla Giordano, Annalinda Pisano, 2014

机译：人线粒体亮氨酰tRNA合成酶的羧基末端结构域可拯救人细胞中线粒体tRNA突变的病理表型
7. Modifying Mitochondrial tRNAs: Delivering What the Cell Needs [O] . Horvath Rita, Chinnery Patrick F. 2015

机译：修改线粒体tRNA：提供细胞所需的物质

Modifying Mitochondrial tRNAs: Delivering What the Cell Needs

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