...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Cell metabolism >Transplanted Bone Marrow-Derived Cells Contribute to Human Adipogenesis
【24h】

Transplanted Bone Marrow-Derived Cells Contribute to Human Adipogenesis

机译：移植的骨髓来源的细胞有助于人类脂肪形成。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Because human white adipocytes display a high turnover throughout adulthood, a continuous supply of precursor cells is required to maintain adipogenesis. Bone marrow (BM)-derived progenitor cells may contribute to mammalian adipogenesis; however, results in animal models are conflicting. Here we demonstrate in 65 subjects who underwent allogeneic BM or peripheral blood stem cell (PBSC) transplantation that, over the entire lifespan, BM/PBSC-derived progenitor cells contribute similar to 10% to the subcutaneous adipocyte population. While this is independent of gender, age, and different transplantation-related parameters, body fat mass exerts a strong influence, with up to 2.5-fold increased donor cell contribution in obese individuals. Exome and whole-genome sequencing of single adipocytes suggests that BM/PBSC-derived progenitors contribute to adipose tissue via both differentiation and cell fusion. Thus, at least in the setting of transplantation, BM serves as a reservoir for adipocyte progenitors, particularly in obese subjects.
机译：由于人类白色脂肪细胞在整个成年期都表现出高周转率，因此需要连续供应前体细胞来维持脂肪形成。骨髓（BM）衍生的祖细胞可能有助于哺乳动物脂肪形成。但是，动物模型中的结果是矛盾的。在这里，我们证明了接受异体BM或外周血干细胞（PBSC）移植的65位受试者在整个生命周期中，BM / PBSC衍生的祖细胞对皮下脂肪细胞的贡献接近10％。尽管这与性别，年龄和与移植相关的参数不同无关，但是体脂肪量产生了很大的影响，供体细胞在肥胖个体中的贡献增加了2.5倍。单个脂肪细胞的外显子组和全基因组测序表明，BM / PBSC衍生的祖细胞通过分化和细胞融合为脂肪组织做出贡献。因此，至少在移植的情况下，BM充当脂肪细胞祖细胞的储存库，特别是在肥胖受试者中。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号