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首页> 外文期刊>La Medicina del lavoro >Introduction: scope and purpose of the multicenter project ' Assessment of effects due to low doses in inorganic mercury following environmental and occupational exposure: human and in vitro studies on specific toxicity mechanisms'
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Introduction: scope and purpose of the multicenter project ' Assessment of effects due to low doses in inorganic mercury following environmental and occupational exposure: human and in vitro studies on specific toxicity mechanisms'

机译：简介：多中心项目的范围和目的“评估环境和职业暴露后低剂量无机汞引起的影响：关于特定毒性机制的人体和体外研究”

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The principal aims of the project financed by the Italian Ministry of University and Scientific and Technological Research were: to verify if at the current limit values early biological effects can be demonstrated; to identify the levels of internal dose that can cause early effects; to evaluate the non-occupational factors that can contribute to the levels of internal dose. In particular, the mercury intake derived from dental amalgams and fish consumption was considered. The internal dose was measured with the traditional biological indicators (urinary and blood mercury) and with the speciation of a large percentage of biological samples by ICP-MS. The central nervous system, neuroendocrine function, kidney and the immune system were considered as target organs and were examined using previously standardized indicators of effects. Two groups of subjects were included in the study: workers with occupational exposure to inorganic mercury in different industrial settings and control subjects identified from the general population. The first group was characterized by an exposure level to inorganic mercury clearly below the current limit values; whereas the HgU levels of a relevant number of control subjects were similar to those measured in the exposed subjects. The in vitro studies covered several issues: the percutaneous absorption of mercury using skin derived from human post-mortem samples in a standardized model; the release of the metal from dental amalgams in different physiological conditions of the oral cavity; the effects of increasing doses of mercury chloride on tubular renal cells. The project was realized with the cooperation of seven Research Units from six Italian Universities. Researchers belonging to Departments of Occupational Medicine, Industrial Hygiene, General Pathology, Biochemistry, Odontology, and Biostatistics were involved to achieve a multidisciplinary approach. The results of this research project are described and discussed in the following papers.
机译：由意大利大学和科学技术研究部资助的项目的主要目的是：验证是否能在目前的极限值上证明早期的生物效应;确定可能导致早期影响的内部剂量水平;评估可能导致内部剂量水平的非职业因素。特别是考虑了来自牙科用汞合金和鱼类食用的汞摄入量。内部剂量使用传统的生物指标（尿液和血液中的汞）以及ICP-MS对很大比例的生物样品进行形态测定。中枢神经系统，神经内分泌功能，肾脏和免疫系统被视为目标器官，并使用先前标准化的作用指标进行检查。研究包括两组受试者：在不同工业环境中职业接触无机汞的工人，以及从普通人群中识别出的对照受试者。第一组的特征是无机汞的暴露水平明显低于当前限值。而相当数量的对照受试者的HgU水平与暴露受试者的HgU水平相似。体外研究涵盖了几个问题：在标准模型中，使用源自人体验尸样品的皮肤对汞进行经皮吸收;在口腔的不同生理条件下从牙科用汞合金释放金属;氯化汞剂量增加对肾小管肾细胞的影响。该项目是由来自意大利六所大学的七个研究部门合作完成的。涉及职业医学，工业卫生，一般病理学，生物化学，牙科学和生物统计学的系的研究人员参与了多学科研究。以下论文描述和讨论了该研究项目的结果。

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