Safety and efficacy of minimally invasive surgery plus alteplase in intracerebral haemorrhage evacuation (MISTIE): a randomised, controlled, open-label, phase 2 trial

Hanley Daniel F.; Thompson Richard E.; Muschelli John; Rosenblum Michael; McBee Nichol; Lane Karen; Bistran-Hall Amanda J.; Mayo Steven W.; Keyl Penelope; Gandhi Dheeraj; Morgan Tim C.; Ullman Natalie; Mould W. Andrew; Carhuapoma J. Ricardo; Kase Carlos; Ziai Wendy; Thompson Carol B.; Yenokyan Gayane; Huang Emily; Broaddus William C.; Graham R. Scott; Aldrich E. Francois; Dodd Robert; Wijman Cristanne; Caron Jean-Louis; Huang Judy; Camarata Paul; Mendelow A. David; Gregson Barbara; Janis Scott; Vespa Paul; Martin Neil; Awad Issam; Zuccarello Mario

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Safety and efficacy of minimally invasive surgery plus alteplase in intracerebral haemorrhage evacuation (MISTIE): a randomised, controlled, open-label, phase 2 trial

机译：微创手术加阿替普酶在脑出血撤离（MISTIE）中的安全性和有效性：一项随机，对照，开放标签的2期临床试验

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Background Craniotomy, according to the results from trials, does not improve functional outcome after intracerebral haemorrhage. Whether minimally invasive catheter evacuation followed by thrombolysis for dot removal is safe and can achieve a good functional outcome is not known. We investigated the safety and efficacy of alteplase, a recombinant tissue plasminogen activator, in combination with minimally invasive surgery (MIS) in patients with intracerebral haemorrhage.

机译：根据试验结果，背景颅骨切开术并不能改善脑出血后的功能预后。目前尚不知道微创导管排空后再进行溶栓去除是否安全并且能否获得良好的功能预后。我们研究了阿替普酶（重组组织纤溶酶原激活剂）与脑出血患者微创手术（MIS）结合的安全性和有效性。

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《Lancet Neurology》 |2016年第12期|共10页
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Hanley Daniel F.; Thompson Richard E.; Muschelli John; Rosenblum Michael; McBee Nichol; Lane Karen; Bistran-Hall Amanda J.; Mayo Steven W.; Keyl Penelope; Gandhi Dheeraj; Morgan Tim C.; Ullman Natalie; Mould W. Andrew; Carhuapoma J. Ricardo; Kase Carlos; Ziai Wendy; Thompson Carol B.; Yenokyan Gayane; Huang Emily; Broaddus William C.; Graham R. Scott; Aldrich E. Francois; Dodd Robert; Wijman Cristanne; Caron Jean-Louis; Huang Judy; Camarata Paul; Mendelow A. David; Gregson Barbara; Janis Scott; Vespa Paul; Martin Neil; Awad Issam; Zuccarello Mario;
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中图分类神经病学与精神病学;
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1. Safety and efficacy of minimally invasive surgery plus alteplase in intracerebral haemorrhage evacuation (MISTIE): a randomised, controlled, open-label, phase 2 trial [J] . Hanley Daniel F., Thompson Richard E., Muschelli John, Lancet Neurology . 2016,第12期

机译：微创手术加阿替普酶在脑出血撤离（MISTIE）中的安全性和有效性：一项随机，对照，开放标签的2期临床试验
2. Efficacy and safety of minimally invasive surgery with thrombolysis in intracerebral haemorrhage evacuation (MISTIE III): a randomised, controlled, open-label, blinded endpoint phase 3 trial (vol 393, pg 1021, 2019) [J] . Hanley D. F., Thompson R. E., Rosenblum M. The Lancet . 2019,第10181期

机译：微创手术在脑内出血疏散中溶栓的疗效和安全性（Mistie III）：随机，受控，开放标签，盲终点第3期试验（Vol 393，PG 1021,2019）
3. Commentary: Efficacy and Safety of Minimally Invasive Surgery With Thrombolysis in Intracerebral Haemorrhage Evacuation (MISTIE III): A Randomized, Controlled, Open-Label, Blinded Endpoint Phase 3 Trial [J] . Neurosurgery . 2020,第5期

机译：评注：微创手术与颅内滴血溶栓的疗效和安全性（Mistie III）：随机，受控，开放标签，蒙蔽终点第3期试验
4. Haemostasis in Minimal Invasive Gynaecological Surgery Energies: Technical Aspects, Safety and Efficacy [C] . V. Tanos, M. Neofytou, C. Pattichis Mediterranean Conference on Medical and Biological Engineering and Computin . 2016

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5. Efficacy and safety of novel collagen conduits filled with collagen filaments to treat patients with peripheral nerve injury: A multicenter, controlled, open-label clinical trial [D] . Saeki Masaomi, 佐伯将臣 2019

机译：充满胶原细丝的新型胶原蛋白导管治疗周围神经损伤患者的疗效和安全性：一项多中心，对照，开放标签的临床试验
6. Safety and efficacy of minimally invasive surgery plus recombinant tissue plasminogen activator in intracerebral haemorrhage evacuation (MISTIE): a randomised phase 2 trial [O] . Daniel F. Hanley, Richard E. Thompson, John Muschelli, -1

机译：微创手术加重组组织纤溶酶原激活剂在脑出血撤离（MISTIE）中的安全性和有效性：一项随机的2期临床试验
7. Efficacy and safety of minimally invasive surgery with thrombolysis in intracerebral haemorrhage evacuation (MISTIE III): a randomised, controlled, open-label, blinded endpoint phase 3 trial [O] . Daniel F Hanley, Richard E Thompson, Michael Rosenblum, 2019

机译：微创手术对脑内出血疏散溶栓的功效和安全性（Mistie III）：随机，控制，开放标签，盲终点第3期试验

Safety and efficacy of minimally invasive surgery plus alteplase in intracerebral haemorrhage evacuation (MISTIE): a randomised, controlled, open-label, phase 2 trial

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