Safety and efficacy of intravenous glyburide on brain swelling after large hemispheric infarction (GAMES-RP): a randomised, double-blind, placebo-controlled phase 2 trial

Sheth Kevin N.; Elm Jordan J.; Molyneaux Bradley J.; Hinson Holly; Beslow Lauren A.; Sze Gordon K.; Ostwaldt Ann-Christin; del Zoppo Gregory J.; Simard J. Marc; Jacobson Sven; Kimberly W. Taylor

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Safety and efficacy of intravenous glyburide on brain swelling after large hemispheric infarction (GAMES-RP): a randomised, double-blind, placebo-controlled phase 2 trial

机译：格列本脲静脉注射对大半球性脑梗死后脑肿胀的安全性和有效性：一项随机，双盲，安慰剂对照的2期试验

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Background Predinical models of stroke have shown that intravenous glyburide reduces brain swelling and improves survival. We assessed whether intravenous glyburide (RP-1127; glibenclamide) would safely reduce brain swelling, decrease the need for decompressive craniectomy, and improve clinical outcomes in patients presenting with a large hemispheric infarction.

机译：背景卒中的常规模型显示静脉内使用格列本脲可以减少脑肿胀并提高生存率。我们评估了静脉内使用格列本脲（RP-1127; glibenclamide）是否可以安全地减轻脑肿胀，减少减压颅骨切除术的需要以及改善患有大半球性脑梗死的患者的临床疗效。

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《Lancet Neurology》 |2016年第11期|共10页
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Sheth Kevin N.; Elm Jordan J.; Molyneaux Bradley J.; Hinson Holly; Beslow Lauren A.; Sze Gordon K.; Ostwaldt Ann-Christin; del Zoppo Gregory J.; Simard J. Marc; Jacobson Sven; Kimberly W. Taylor;
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中图分类神经病学与精神病学;
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机译：格列本脲静脉注射对大半球性脑梗死后脑肿胀的安全性和有效性：一项随机，双盲，安慰剂对照的2期试验
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Safety and efficacy of intravenous glyburide on brain swelling after large hemispheric infarction (GAMES-RP): a randomised, double-blind, placebo-controlled phase 2 trial

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