Cortical atrophy in patients with cerebral amyloid angiopathy: a case-control study

Fotiadis Panagiotis; van Rooden Sanneke; van der Grond Jeroen; Schultz Aaron; Martinez-Ramirez Sergi; Auriel Eitan; Reijmer Yael; van Opstal Anna M.; Ayres Alison; Schwab Kristin M.; Hedden Trey; Rosand Jonathan; Viswanathan Anand; Wermer Marieke; Terwindt Gisela M.; Sperling Reisa A.; Polimeni Jonathan R.; Johnson Keith A.; van Buchem Mark A.; Greenberg Steven M.; Gurol M. Edip

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Cortical atrophy in patients with cerebral amyloid angiopathy: a case-control study

机译：脑淀粉样血管病患者的皮质萎缩：病例对照研究

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Background Loss of cortical grey matter is a diagnostic marker of many neurodegenerative diseases, and is a key mediator of cognitive impairment. We postulated that cerebral amyloid angiopathy (CAA), characterised by cortical vascular amyloid deposits, is associated with cortical tissue loss independent of parenchymal Alzheimer's disease pathology. We tested this hypothesis in patients with hereditary cerebral haemorrhage with amyloidosis-Dutch type (HCHWA-D), a monogenetic disease with minimal or no concomitant Alzheimer's disease pathology, as well as in patients with sporadic CAA and healthy and Alzheimer's disease controls.

机译：背景皮质灰质的丢失是许多神经退行性疾病的诊断标志，并且是认知障碍的关键介质。我们假设脑淀粉样血管病（CAA）的特征是皮质血管淀粉样蛋白沉积，与皮质组织损失无关，与实质性阿尔茨海默氏病病理无关。我们在患有淀粉样变性-荷兰型（HCHWA-D）的遗传性脑出血患者，患有最小限度或没有伴随阿尔茨海默氏病病理的单基因疾病以及散发CAA以及健康和阿尔茨海默氏病对照患者中测试了这一假设。

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《Lancet Neurology》 |2016年第8期|共9页
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Fotiadis Panagiotis; van Rooden Sanneke; van der Grond Jeroen; Schultz Aaron; Martinez-Ramirez Sergi; Auriel Eitan; Reijmer Yael; van Opstal Anna M.; Ayres Alison; Schwab Kristin M.; Hedden Trey; Rosand Jonathan; Viswanathan Anand; Wermer Marieke; Terwindt Gisela M.; Sperling Reisa A.; Polimeni Jonathan R.; Johnson Keith A.; van Buchem Mark A.; Greenberg Steven M.; Gurol M. Edip;
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中图分类神经病学与精神病学;
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1. Cortical atrophy in patients with cerebral amyloid angiopathy: a case-control study [J] . Fotiadis Panagiotis, van Rooden Sanneke, van der Grond Jeroen, Lancet Neurology . 2016,第8期

机译：脑淀粉样血管病患者的皮质萎缩：病例对照研究
2. Cortical Microinfarcts on 3T Magnetic Resonance Imaging in Cerebral Amyloid Angiopathy: Relations With Other Magnetic Resonance Imaging Markers of Cerebral Amyloid Angiopathy and Cognition [J] . van den Brink Hilde, Zwiers Angela, Switzer Aaron R., Stroke: A Journal of Cerebral Circulation . 2018,第8期

机译：脑淀粉样术血管病的3T磁共振成像的皮质微因病：与脑淀粉样血管病和认知的其他磁共振成像标记的关系
3. ApoA-I deficiency increases cortical amyloid deposition, cerebral amyloid angiopathy, cortical and hippocampal astrogliosis, and amyloid-associated astrocyte reactivity in APP/PS1 mice [J] . Emily B. Button, Guilaine K. Boyce, Anna Wilkinson, Alzheimer s Research & Therapy . 2019,第1期

机译：ApoA-I缺乏会增加APP / PS1小鼠的皮质淀粉样蛋白沉积，脑淀粉样血管病，皮质和海马星形胶质增生以及淀粉样蛋白相关的星形胶质细胞反应性
4. HEREDITARY CEREBRAL AMYLOID ANGIOPATHY ASSOCIATED WITH A NOVEL AMYLOID BETA PRECURSOR PROTEIN MUTATION [C] . L Obici, G. De Rosa, G. Pailadini, International Symposium on Amyloidosis . 2005

机译：与新型淀粉样蛋白β前体蛋白突变相关的遗传性脑淀粉样血管病
5. Apolipoprotein E Immunotherapy for the Preclinical Treatment of Alzheimer Disease and Cerebral Amyloid Angiopathy [D] . Xiong, Monica. 2021

机译：Alzheimer病和脑淀粉样血管病的临床前治疗载脂蛋白E免疫疗法
6. Cortical Atrophy in Hereditary and Sporadic Forms of Cerebral Amyloid Angiopathy: an observational case-control study [O] . Panagiotis Fotiadis, Sanneke van Rooden, Jeroen van der Grond, -1

机译：遗传性和散发性形式的大脑淀粉样血管病的皮质萎缩：观察性病例对照研究
7. Cortical atrophy in patients with cerebral amyloid angiopathy: a case-control study [O] . Fotiadis Panagiotis, van Rooden Sanneke, van der Grond Jeroen, 2016

机译：脑淀粉样血管病患者的皮质萎缩：病例对照研究

Cortical atrophy in patients with cerebral amyloid angiopathy: a case-control study

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