CSF and blood biomarkers for the diagnosis of Alzheimer's disease: a systematic review and meta-analysis

Olsson Bob; Lautner Ronald; Andreasson Ulf; Ohrfelt Annika; Portelius Erik; Bjerke Maria; Holtta Mikko; Rosen Christoffer; Olsson Caroline; Strobel Gabrielle; Wu Elizabeth; Dakin Kelly; Petzold Max; Blennow Kaj; Zetterberg Henrik

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CSF and blood biomarkers for the diagnosis of Alzheimer's disease: a systematic review and meta-analysis

机译：脑脊液和血液生物标记物对阿尔茨海默氏病的诊断：系统评价和荟萃分析

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Background Alzheimer's disease biomarkers areimportant for early diagnosis in routine clinical practice and research. Three core CSF biomarkers for the diagnosis of Alzheimer's disease (A beta 42, T-tau, and P-tau) have been assessed in numerous studies, and several other Alzheimer's disease markers are emerging in the literature. However, there have been no comprehensive meta-analyses of their diagnostic performance. We systematically reviewed the literature for 15 biomarkers in both CSF and blood to assess which of these were most altered in Alzheimer's disease.

机译：背景阿尔茨海默氏病生物标志物对于常规临床实践和研究中的早期诊断很重要。在众多研究中已经评估了三种用于诊断阿尔茨海默氏病的核心CSF生物标志物（A beta 42，T-tau和P-tau），并且文献中还出现了其他几种阿尔茨海默氏病标志物。但是，尚未对其诊断性能进行全面的荟萃分析。我们系统地回顾了脑脊液和血液中15种生物标志物的文献，以评估其中哪些在阿尔茨海默氏病中变化最大。

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《Lancet Neurology》 |2016年第7期|共12页
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Olsson Bob; Lautner Ronald; Andreasson Ulf; Ohrfelt Annika; Portelius Erik; Bjerke Maria; Holtta Mikko; Rosen Christoffer; Olsson Caroline; Strobel Gabrielle; Wu Elizabeth; Dakin Kelly; Petzold Max; Blennow Kaj; Zetterberg Henrik;
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中图分类神经病学与精神病学;
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1. CSF and blood biomarkers for the diagnosis of Alzheimer's disease: a systematic review and meta-analysis [J] . Olsson Bob, Lautner Ronald, Andreasson Ulf, Lancet Neurology . 2016,第7期

机译：脑脊液和血液生物标记物对阿尔茨海默氏病的诊断：系统评价和荟萃分析
2. Proteomics as a reliable approach for discovery of blood-based Alzheimer's disease biomarkers: A systematic review and meta-analysis [J] . Rehiman Siti Hajar, Lim Siong Meng, Neoh Chin Fen, Ageing Research Reviews . 2020,第期

机译：蛋白质组学作为发现血基阿尔茨海默病生物标志物的可靠方法：系统审查和荟萃分析
3. Blood circulating miRNAs as biomarkers of Alzheimer's disease: a systematic review and meta-analysis [J] . Zhang Ya-Heng, Bai Shu-Feng, Yan Jun-Qiang Biomarkers in medicine . 2019,第12期

机译：血液循环miRNA作为阿尔茨海默病的生物标志物：系统审查和荟萃分析
4. Identification of Optimum Panel of Blood-based Biomarkers for Alzheimer’s Disease Diagnosis Using Machine Learning [C] . C. S. Eke, E. Jammeh, X. Li, Annual International Conference of the IEEE Engineering in Medicine and Biology Society . 2018

机译：使用机器学习识别用于阿尔茨海默氏病诊断的最佳血液生物标记物
5. The Effect of Hormone Replacement Therapy (HRT) on Cognition and Dementia Including Alzheimer’s Disease: A Systematic Review and Network Meta-Analysis [D] . Pitt, Devondra. 2021

机译：激素替代疗法（HRT）对包括阿尔茨海默病的认知和痴呆的影响：系统审查和网络元分析
6. The diagnostic performance of neurofilament light chain in CSF and blood for Alzheimers disease frontotemporal dementia and amyotrophic lateral sclerosis: A systematic review and meta-analysis [O] . Lauren M. Forgrave, Matthew Ma, John R. Best, 2019

机译：脑脊液和血液中神经丝轻链对阿尔茨海默氏病额颞痴呆和肌萎缩性侧索硬化的诊断性能：系统评价和荟萃分析
7. CSF and blood biomarkers in amyotrophic lateral sclerosis: protocol for a systematic review and meta-analysis [O] . Elmira Agah, Fatemeh Saleh, Hossein Sanjari Moghaddam, 2018

机译：肌营养侧面硬化症中的CSF和血液生物标志物：系统审查和荟萃分析的协议

CSF and blood biomarkers for the diagnosis of Alzheimer's disease: a systematic review and meta-analysis

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