Prehospital treatment with levetiracetam plus clonazepam or placebo plus clonazepam in status epilepticus (SAMUKeppra): a randomised, double-blind, phase 3 trial

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Prehospital treatment with levetiracetam plus clonazepam or placebo plus clonazepam in status epilepticus (SAMUKeppra): a randomised, double-blind, phase 3 trial

机译：左乙拉西坦加氯硝西am或安慰剂加氯硝西am用于癫痫持续状态的院前治疗（SAMUKeppra）：一项随机，双盲，3期临床试验

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Background Generalised convulsive status epilepticus (GCSE) should be treated quickly. Benzodiazepines are the only drug treatment available so far that is effective before admission to hospital. We assessed whether addition of the antiepileptic drug levetiracetam to the benzodiazepine clonazepam would improve prehospital treatment of GCSE.

机译：背景广泛的惊厥性癫痫持续状态（GCSE）应迅速治疗。苯二氮卓类药物是迄今为止入院前唯一有效的药物治疗方法。我们评估了将抗癫痫药左乙拉西坦加至苯二氮卓类氯硝西am是否会改善GCSE的院前治疗。

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《Lancet Neurology》 |2016年第1期|共9页
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中图分类神经病学与精神病学;
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1. Prehospital treatment with levetiracetam plus clonazepam or placebo plus clonazepam in status epilepticus (SAMUKeppra): a randomised, double-blind, phase 3 trial [J] . Lancet Neurology . 2016,第1期

机译：左乙拉西坦加氯硝西am或安慰剂加氯硝西am用于癫痫持续状态的院前治疗（SAMUKeppra）：一项随机，双盲，3期临床试验
2. RAMPART (Rapid Anticonvulsant Medication Prior to Arrival Trial): a double-blind randomized clinical trial of the efficacy of intramuscular midazolam versus intravenous lorazepam in the prehospital treatment of status epilepticus by paramedics. [J] . Silbergleit R, Lowenstein D, Durkalski V, Epilepsia: Journal of the International League against Epilepsy . 2011,第Suppla8期

机译：RAMPART（抵港前快速抗惊厥药物）：咪达唑仑与静脉注射劳拉西m在院前医护人员对癫痫持续状态的疗效双盲随机临床试验。
3. Levetiracetam versus phenytoin for second-line treatment of convulsive status epilepticus in children (ConSEPT): an open-label, multicentre, randomised controlled trial [J] . Dalziel Stuart R., Borland Meredith L., Furyk Jeremy, The Lancet . 2019,第10186期

机译：Levetiracetam对儿童痉挛状态癫痫患者的二线治疗（CONSEPT）：开放标签，多期，随机对照试验
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6. Emergency treatment with levetiracetam or phenytoin in status epilepticus in children—the EcLiPSE study: study protocol for a randomised controlled trial [O] . Mark D. Lyttle, Carrol Gamble, Shrouk Messahel, 2017

机译：儿童癫痫持续状态中左乙拉西坦或苯妥英钠的紧急治疗—EcLiPSE研究：一项随机对照试验的研究方案
7. Efficacy of levetiracetam, fosphenytoin, and valproate for established status epilepticus by age group (ESETT): a double-blind, responsive-adaptive, randomised controlled trial [O] . James M Chamberlain, Jaideep Kapur, Shlomo Shinnar, 2020

机译：Levetiracetam，Falphenytoin和Valproate对已建立的状态癫痫的疗效（Esett）：双盲，响应性适应性，随机对照试验

Prehospital treatment with levetiracetam plus clonazepam or placebo plus clonazepam in status epilepticus (SAMUKeppra): a randomised, double-blind, phase 3 trial

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