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首页> 外文期刊>Lancet Neurology >Amyotrophic lateral sclerosis and frontotemporal dementia: distinct and overlapping changes in eating behaviour and metabolism
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Amyotrophic lateral sclerosis and frontotemporal dementia: distinct and overlapping changes in eating behaviour and metabolism

机译：肌萎缩性侧索硬化症和额颞痴呆：进食行为和新陈代谢发生明显且重叠的变化

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Metabolic changes incorporating fluctuations in weight, insulin resistance, and cholesterol concentrations have been identified in several neurodegenerative disorders. Whether these changes result from the neurodegenerative process affecting brain regions necessary for metabolic regulation or whether they drive the degenerative process is unknown. Emerging evidence from epidemiological, clinical, pathological, and experimental studies emphasises a range of changes in eating behaviours and metabolism in amyotrophic lateral sderosis (ALS) and frontotemporal dementia (FTD). In ALS, metabolic changes have been linked to disease progression and prognosis. Furthermore, changes in eating behaviour that affect metabolism have been incorporated into the diagnostic criteria for FTD, which has some clinical and pathological overlap with ALS. Whether the distinct and shared metabolic and eating changes represent a component of the proposed spectrum of the two diseases is an intriguing possibility. Moreover, future research should aim to unravel the complex connections between eating, metabolism, and neurodegeneration in ALS and FTD, and aim to understand the potential for targeting modifiable risk factors in disease development and progression.
机译：在几种神经退行性疾病中，已发现代谢变化包括体重，胰岛素抵抗和胆固醇浓度的波动。这些变化是否是由于神经退行性过程影响代谢调节所必需的大脑区域而引起的，还是它们是否驱动了退行性过程尚不清楚。流行病学，临床，病理学和实验研究的新证据强调，肌萎缩性侧支皮损（ALS）和额颞痴呆（FTD）的饮食行为和新陈代谢发生了一系列变化。在ALS中，代谢变化与疾病进展和预后有关。此外，影响新陈代谢的饮食行为改变已被纳入FTD的诊断标准，该诊断标准与ALS在临床和病理上有重叠。独特的和共有的代谢变化和饮食变化是否代表了两种疾病的拟议范围的一个组成部分，这很有意思。此外，未来的研究应旨在揭示ALS和FTD中进食，代谢和神经退行性变之间的复杂联系，并旨在了解针对疾病发展和进展中可改变的危险因素的潜力。

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