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首页> 外文期刊>Lancet Neurology >Pisa syndrome in Parkinson's disease and parkinsonism: clinical features, pathophysiology, and treatment
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Pisa syndrome in Parkinson's disease and parkinsonism: clinical features, pathophysiology, and treatment

机译：帕金森氏病和帕金森氏症的比萨综合征：临床特征，病理生理学和治疗

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Pisa syndrome is defined as a reversible lateral bending of the trunk with a tendency to lean to one side. It is a frequent and often disabling complication of Parkinson's disease, and has also been described in several atypical forms of parkinsonism and in neurodegenerative and psychiatric disorders after drug exposure and surgical procedures. Although no consistent diagnostic criteria for Pisa syndrome are available, most investigations have adopted an arbitrary cutoff of at least 10 degrees of lateral flexion for the diagnosis of the syndrome. Pathophysiological mechanisms underlying Pisa syndrome have not been fully explained. One hypothesis emphasises central mechanisms, whereby Pisa syndrome is thought to be caused by alterations in sensory-motor integration pathways; by contrast, a peripheral hypothesis emphasises the role of anatomical changes in the musculoskeletal system. Furthermore, several drugs are reported to induce Pisa syndrome, including antiparkinsonian drugs. As Pisa syndrome might be reversible, clinicians need to be able to recognise this condition early to enable prompt management. Nevertheless, further research is needed to determine optimum treatment strategies.
机译：比萨综合症定义为躯干可逆的横向弯曲，倾向于向一侧倾斜。它是帕金森氏病的常见并发症，通常是致残性并发症，而且已在多种非典型形式的帕金森氏病以及药物暴露和手术后的神经退行性疾病和精神疾病中描述。尽管没有关于比萨综合症的一致诊断标准，但是大多数研究已经采用了至少弯曲10度的任意截断来诊断该综合症。比萨综合症的病理生理机制尚未完全阐明。一种假设强调中心机制，据认为比萨综合症是由感觉运动整合途径的改变引起的。相比之下，外围假设则强调了解剖变化在肌肉骨骼系统中的作用。此外，据报道有几种药物可诱发比萨综合症，包括抗帕金森病药物。由于比萨综合症可能是可逆的，因此临床医生需要能够及早识别出这种情况，以便迅速进行治疗。然而，需要进一步的研究来确定最佳的治疗策略。

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