Leptin does not directly affect CNS serotonin neurons to influence appetite.

Lam DD; Leinninger GM; Louis GW; Garfield AS; Marston OJ; Leshan RL; Scheller EL; Christensen L; Donato J Jr; Xia J; Evans ML; Elias C; Dalley JW; Burdakov DI; Myers MG Jr; Heisler LK

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Leptin does not directly affect CNS serotonin neurons to influence appetite.

机译：瘦素不会直接影响中枢神经系统5-羟色胺神经元的食欲。

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Serotonin (5-HT) and leptin play important roles in the modulation of energy balance. Here we investigated mechanisms by which leptin might interact with CNS 5-HT pathways to influence appetite. Although some leptin receptor (LepRb) neurons lie close to 5-HT neurons in the dorsal raphe (DR), 5-HT neurons do not express LepRb. Indeed, while leptin hyperpolarizes some non-5-HT DR neurons, leptin does not alter the activity of DR 5-HT neurons. Furthermore, 5-HT depletion does not impair the anorectic effects of leptin. The serotonin transporter-cre allele (Sert(cre)) is expressed in 5-HT (and developmentally in some non-5-HT) neurons. While Sert(cre) promotes LepRb excision in a few LepRb neurons in the hypothalamus, it is not active in DR LepRb neurons, and neuron-specific Sert(cre)-mediated LepRb inactivation in mice does not alter body weight or adiposity. Thus, leptin does not directly influence 5-HT neurons and does not meaningfully modulate important appetite-related determinants via 5-HT neuron function.

机译：血清素（5-HT）和瘦素在调节能量平衡中起重要作用。在这里，我们研究了瘦素可能与中枢神经系统5-HT途径相互作用以影响食欲的机制。尽管一些瘦蛋白受体（LepRb）神经元在背缝（DR）中位于5-HT神经元附近，但5-HT神经元不表达LepRb。确实，尽管瘦素使某些非5-HT DR神经元超极化，但瘦素不会改变DR 5-HT神经元的活性。此外，5-HT耗竭不损害瘦素的厌食作用。血清素转运蛋白-cre等位基因（Sert（cre））在5-HT（并且在某些非5-HT）神经元中表达。尽管Sert（cre）促进下丘脑中少数LepRb神经元的LepRb切除，但它在DR LepRb神经元中不起作用，并且神经元特异性Sert（cre）介导的LepRb灭活不会改变体重或肥胖。因此，瘦素不会直接影响5-HT神经元，也不会通过5-HT神经元功能有意义地调节重要的食欲相关决定因素。

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《Cell metabolism》 |2011年第5期|共8页
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Lam DD; Leinninger GM; Louis GW; Garfield AS; Marston OJ; Leshan RL; Scheller EL; Christensen L; Donato J Jr; Xia J; Evans ML; Elias C; Dalley JW; Burdakov DI; Myers MG Jr; Heisler LK;
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1. Leptin does not directly affect CNS serotonin neurons to influence appetite. [J] . Lam DD, Leinninger GM, Louis GW, Cell metabolism . 2011,第5期

机译：瘦素不会直接影响中枢神经系统5-羟色胺神经元的食欲。
2. Leptin directly activates SF1 neurons in the VMH, and this action by leptin is required for normal body-weight homeostasis. [J] . Dhillon H, Zigman JM, Ye C, Neuron . 2006,第2期

机译：瘦素直接激活VMH中的SF1神经元，瘦体重的这种作用是正常体重体内平衡所必需的。
3. Leptin directly regulate intrinsic neuronal excitability in hypothalamic POMC neurons but not in AgRP neurons in food restricted mice [J] . Lee Soojung, Lee Jooyoung, Kang Gil Myoung, Neuroscience Letters: An International Multidisciplinary Journal Devoted to the Rapid Publication of Basic Research in the Brain Sciences . 2018,第期

机译：瘦素直接调节下丘脑POMC神经元的内在神经元兴奋性，但在食品受限制小鼠的Agrp神经元中
4. Modelling the Effect of Dorsal Raphe Serotonin Neurons on Patience for Future Rewards [C] . Marc Sutherland, Bernd Porr International conference on simulation of adaptive behavior . 2016

机译：建模背缝的5-羟色胺神经元对耐心的影响，为将来的奖励
5. Motherhood, Stress, and Serotonin Receptors – Influence on Postpartum Social and Affective Behaviors in Female Laboratory Rats [D] . ?Vitale, Erika 2020

机译：母亲，压力和血清素受体 - 在雌性实验鼠在产后的社会和情感行为的影响
6. Leptin does not directly affect CNS serotonin neurons to influence appetite [O] . Daniel D. Lam, Gina M. Leinninger, Gwendolyn W. Louis, -1

机译：瘦素不会直接影响CNS血清素神经元以影响食欲
7. Leptin Does Not Directly Affect CNS Serotonin Neurons to Influence Appetite [O] . Lam, Daniel D., Leinninger, Gina M., Louis, Gwendolyn W., 2011

机译：瘦素不会直接影响中枢神经系统5-羟色胺神经元的食欲。

Leptin does not directly affect CNS serotonin neurons to influence appetite.

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