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首页> 外文期刊>Cell metabolism >Intramyocellular fatty-acid metabolism plays a critical role in mediating responses to dietary restriction in drosophila melanogaster
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Intramyocellular fatty-acid metabolism plays a critical role in mediating responses to dietary restriction in drosophila melanogaster

机译：肌内脂肪酸代谢在果蝇的饮食限制反应中起关键作用

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摘要

Changes in fat content have been associated with dietary restriction (DR), but whether they play a causal role in mediating various responses to DR remains unknown. We demonstrate that upon DR, Drosophila melanogaster shift their metabolism toward increasing fatty-acid synthesis and breakdown, which is required for various responses to DR. Inhibition of fatty-acid synthesis or oxidation genes specifically in the muscle tissue inhibited life-span extension upon DR. Furthermore, DR enhances spontaneous activity of flies, which was found to be dependent on the enhanced fatty-acid metabolism. This increase in activity was found to be at least partially required for the life-span extension upon DR. Overexpression of adipokinetic hormone (dAKH), the functional ortholog of glucagon, enhances fat metabolism, spontaneous activity, and life span. Together, these results suggest that enhanced fat metabolism in the muscle and physical activity play a key role in the protective effects of DR.
机译：脂肪含量的变化与饮食限制（DR）有关，但是它们是否在介导对DR的各种反应中起因果作用仍然未知。我们证明，在DR上，果蝇将其新陈代谢转移到增加脂肪酸合成和分解的过程中，这是对DR的各种反应所必需的。特别是在肌肉组织中抑制脂肪酸合成或氧化基因会抑制DR的寿命延长。此外，DR增强了果蝇的自发活性，这被发现依赖于增强的脂肪酸代谢。发现活动的增加至少是DR寿命延长所需的。胰高血糖素的功能性直系同源物，脂肪代谢激素（dAKH）的过量表达可增强脂肪代谢，自发活动和寿命。总之，这些结果表明增强的肌肉脂肪代谢和身体活动在DR的保护作用中起关键作用。

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