How adenosine receptors protect the ischemic heart is not completely understood. Eckle et al. (2012) now show that signaling through adenosine receptor 2b (Adora2b) stabilizes a circadian rhythm protein, period 2 (Per2), resulting in the stabilization of hypoxia-inducible factor-1α (HIF-1α), upregulation of glycolysis, and cardioprotection from ischemia.
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