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首页> 外文期刊>Cell metabolism >Coordination of triacylglycerol and cholesterol homeostasis by DHR96 and the drosophila lipa homolog magro
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Coordination of triacylglycerol and cholesterol homeostasis by DHR96 and the drosophila lipa homolog magro

机译：DHR96和果蝇果蝇同源物对三酰甘油和胆固醇稳态的协调作用

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Although transintestinal cholesterol efflux has been identified as an important means of clearing excess sterols, the mechanisms that underlie this process remain poorly understood. Here, we show that magro, a direct target of the Drosophila DHR96 nuclear receptor, is required in the intestine to maintain cholesterol homeostasis. magro encodes a LipA homolog that is secreted from the anterior gut into the intestinal lumen to digest dietary triacylglycerol. Expression of magro in intestinal cells is required to hydrolyze cholesterol esters and promote cholesterol clearance. Restoring magro expression in the intestine of DHR96 mutants rescues their defects in triacylglycerol and cholesterol metabolism. These studies show that the central role of the intestine in cholesterol efflux has been conserved through evolution, that the ancestral function of LipA is to coordinate triacylglycerol and cholesterol metabolism, and that the region-specific activities of magro correspond to the metabolic functions of its upstream regulator, DHR96.
机译：尽管跨肠胆固醇外流已被确认为清除过量固醇的重要手段，但对该过程的基础机制仍知之甚少。在这里，我们表明果蝇是果蝇DHR96核受体的直接靶标，在肠道中需要维持胆固醇稳态。 magro编码从前肠分泌到肠腔中的LipA同源物，以消化饮食中的三酰甘油。肠道细胞中黑麦表达需要水解胆固醇酯并促进胆固醇清除。恢复DHR96突变体肠道中的黑麦表达，可以挽救它们在三酰基甘油和胆固醇代谢中的缺陷。这些研究表明，肠在胆固醇外排中的核心作用通过进化得以保留，LipA的祖先功能是协调三酰甘油和胆固醇代谢，并且黑麦的区域特定活性与其上游的代谢功能相对应。调节器，DHR96。

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