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首页> 外文期刊>Cell metabolism >Ghrelin modulates brain activity in areas that control appetitive behavior.
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Ghrelin modulates brain activity in areas that control appetitive behavior.

机译：Ghrelin在控制食欲行为的区域调节大脑活动。

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Feeding behavior is often separated into homeostatic and hedonic components. Hedonic feeding, which can be triggered by visual or olfactory food cues, involves brain regions that play a role in reward and motivation, while homeostatic feeding is thought to be under the control of circulating hormones acting primarily on the hypothalamus. Ghrelin is a peptide hormone secreted by the gut that causes hunger and food consumption. Here, we show that ghrelin administered intravenously to healthy volunteers during functional magnetic resonance imaging increased the neural response to food pictures in regions of the brain, including the amygdala, orbitofrontal cortex, anterior insula, and striatum, implicated in encoding the incentive value of food cues. The effects of ghrelin on the amygdala and OFC response were correlated with self-rated hunger ratings. This demonstrates that metabolic signals such as ghrelin may favor food consumption by enhancing the hedonic and incentive responses to food-related cues.
机译：进食行为通常分为稳态和享乐成分。由视觉或嗅觉食物暗示触发的享乐性喂养涉及大脑区域，在奖励和动机中发挥作用，而稳态喂养则受主要作用于下丘脑的循环激素的控制。 Ghrelin是肠道分泌的一种肽激素，可导致饥饿和食物消耗。在这里，我们显示，在功能磁共振成像过程中向健康志愿者静脉注射生长素释放肽可增加对大脑区域（包括杏仁核，眶额皮质，前岛和纹状体）食物图像的神经反应，这与编码食物的激励价值有关提示。 ghrelin对杏仁核和OFC反应的影响与自我评估的饥饿评估相关。这表明，诸如生长素释放肽之类的代谢信号可能通过增强对食物相关线索的享乐性和刺激性反应而有利于食物消费。

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