Proteostasis impairment: At the intersection between Alzheimer's disease and diabetes

MedinasD.B.; HetzC.

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Proteostasis impairment: At the intersection between Alzheimer's disease and diabetes

机译：蛋白质变性障碍：在阿尔茨海默氏病和糖尿病之间的交集处

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Altered insulin signaling and neuroinflammation are emerging features of Alzheimer's disease. Lourenco et al. (2013) identify a pathogenic mechanism that is shared between Alzheimer's disease and diabetes and contributes to memory loss through a common molecular event: the control of protein synthesis by PKR and the downstream phosphorylation of eIF2α.

机译：改变的胰岛素信号传导和神经炎症是阿尔茨海默氏病的新兴特征。 Lourenco等。（2013年）确定了一种在阿尔茨海默氏病和糖尿病之间共有的致病机制，并通过一个常见的分子事件导致记忆丧失：PKR控制蛋白质合成和eIF2α的下游磷酸化。

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《Cell metabolism》 |2013年第6期|共2页
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MedinasD.B.; HetzC.;
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中图分类内分泌腺疾病及代谢病;
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1. Proteostasis impairment: At the intersection between Alzheimer's disease and diabetes [J] . MedinasD.B., HetzC. Cell metabolism . 2013,第6期

机译：蛋白质变性障碍：在阿尔茨海默氏病和糖尿病之间的交集处
2. Empagliflozin reduces vascular damage and cognitive impairment in a mixed murine model of Alzheimer’s disease and type 2 diabetes [J] . Carmen Hierro-Bujalance, Carmen Infante-Garcia, Angel del Marco, Alzheimer s Research & Therapy . 2020,第1期

机译：Empagliflozin在阿尔茨海默病的混合鼠模型中降低了血管损伤和认知障碍，以及2型糖尿病
3. Impaired cerebral blood flow in type 2 diabetes mellitus – A comparative study with subjective cognitive decline, vascular dementia and Alzheimer’s disease subjects [J] . Anson C.M. Chau, Eva Y.W. Cheung, K.H. Chan, NeuroImage: Clinical . 2020,第1期

机译：2型糖尿病患者的脑血流量受损 - 具有主观认知下降，血管痴呆和阿尔茨海默病科目的比较研究
4. THE STORY BEHIND THE DISCOVERY OF NATURE-INSPIRED SUGAR CONJUGATES WITH THERAPEUTIC POTENTIAL AGAINST DIABETES AND ALZHEIMER'S DISEASE [C] . Ana M. Matos, Teresa Man, Magnus Walter International Carbohydrate Symposium . 2018

机译：对糖尿病患者和阿尔茨海默病的治疗潜力发现自然启发糖共轭物背后的故事
5. The novel use of recombinant granulocyte-macrophage colony stimulating factor (GM-CSF) to reverse cerebral amyloidosis and cognitive impairment in Alzheimer's disease mouse models: Insights from the investigation of Rheumatoid arthritis as a negative risk factor for Alzheimer's disease [D] . Boyd, Timothy David 2010

机译：重组粒细胞巨噬细胞集落刺激因子（GM-CSF）在阿尔茨海默氏病小鼠模型中逆转脑淀粉样变性和认知障碍的新用途：类风湿关节炎作为阿尔茨海默氏病的阴性危险因素研究的启示
6. Impairment of proteostasis network in Down syndrome prior to the development of Alzheimer’s disease neuropathology: Redox proteomics analysis of human brain [O] . Fabio Di Domenico, Raffaella Coccia, Annalisa Cocciolo, -1

机译：阿尔茨海默氏病神经病理学发展之前唐氏综合症中的蛋白质稳态网络受损：人脑的氧化还原蛋白质组学分析
7. Proteostasis Impairment: At the Intersection between Alzheimer’s Disease and Diabetes [O] . Medinas Danilo B., Hetz Claudio 2013

机译：蛋白质变性障碍：在阿尔茨海默氏病和糖尿病之间的交汇处

Proteostasis impairment: At the intersection between Alzheimer's disease and diabetes

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