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首页> 外文期刊>Cell metabolism >Stukas, S., Robert, J., Wellington, C.L.High-density lipoproteins and cerebrovascular integrity in Alzheimer's disease
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Stukas, S., Robert, J., Wellington, C.L.High-density lipoproteins and cerebrovascular integrity in Alzheimer's disease

机译：Stukas，S.，Robert，J.，Wellington，C.高密度脂蛋白和阿尔茨海默氏病的脑血管完整性

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摘要

Cerebrovascular dysfunction significantly contributes to the clinical presentation and pathoetiology of Alzheimer's disease (AD). Deposition and aggregation of β-amyloid (Aβ) within vascular smooth muscle cells leads to inflammation, oxidative stress, impaired vasorelaxation, and disruption of blood-brain barrier integrity. Midlife vascular risk factors, such as hypertension, cardiovascular disease, diabetes, and dyslipidemia, increase the relative risk for AD. These comorbidities are all characterized by low and/or dysfunctional high-density lipoproteins (HDL), which itself is a risk factor for AD. HDL performs a wide variety of critical functions in the periphery and CNS. In addition to lipid transport, HDL regulates vascular health via mediating vasorelaxation, inflammation, and oxidative stress and promotes endothelial cell survival and integrity. Here, we summarize clinical and preclinical data examining the involvement of HDL, originating from the circulation and from within the CNS, on AD and hypothesize potential synergistic actions between the two lipoprotein pools.
机译：脑血管功能障碍是阿尔茨海默氏病（AD）的临床表现和病理学显着原因。 β-淀粉样蛋白（Aβ）在血管平滑肌细胞内的沉积和聚集会导致炎症，氧化应激，血管舒张受损和血脑屏障完整性破坏。中年血管危险因素，例如高血压，心血管疾病，糖尿病和血脂异常，增加了AD的相对风险。这些合并症均以低密度和/或功能异常的高密度脂蛋白（HDL）为特征，而高脂蛋白本身就是AD的危险因素。 HDL在外围设备和CNS中执行各种关键功能。除脂质转运外，HDL还通过介导血管舒张，炎症和氧化应激来调节血管健康，并促进内皮细胞的存活和完整性。在这里，我们总结了临床和临床前数据，这些数据检查了HDL在循环系统中和CNS内对AD的参与，并假设了两个脂蛋白池之间潜在的协同作用。

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