SUMOylation places LRH-1 in PROXimity to lipid metabolism

PriestC.; TontonozP.

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SUMOylation places LRH-1 in PROXimity to lipid metabolism

机译：SUMOylation使LRH-1接近脂质代谢

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The development of atherosclerosis is countered by the reverse transport of cholesterol from peripheral tissues to the liver for excretion. In this issue of Cell Metabolism, Stein et al. (2014) establish LRH-1 as an important regulator of reverse cholesterol transport and identify SUMOylation as a primary mode of LRH-1 regulation.

机译：胆固醇从周围组织向肝脏排泄的逆向转运可抵制动脉粥样硬化的发展。在本期《细胞代谢》一书中，Stein等人。（2014）建立LRH-1作为胆固醇逆向转运的重要调节剂，并将SUMOylation确定为LRH-1调节的主要方式。

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《Cell metabolism》 |2014年第4期|共2页
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PriestC.; TontonozP.;
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中图分类内分泌腺疾病及代谢病;
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1. SUMOylation places LRH-1 in PROXimity to lipid metabolism [J] . PriestC., TontonozP. Cell metabolism . 2014,第4期

机译：SUMOylation使LRH-1接近脂质代谢
2. Impaired SUMOylation of nuclear receptor LRH-1 promotes nonalcoholic fatty liver disease [J] . Sokrates Stein, Vera Lemos, Pan Xu, The journal of clinical investigation . 2017,第2期

机译：核受体LRH-1的SUMOylation受损会促进非酒精性脂肪肝疾病
3. A gene-expression screen identifies a non-toxic sumoylation inhibitor that mimics SUMO-less human LRH-1 in liver [J] . Miyuki Suzawa, Diego A Miranda, Karmela A Ramos, eLife journal . 2015,第november期

机译：基因表达筛选可鉴定出一种无毒的磺酰化抑制剂，该抑制剂可模拟肝脏中无SUMO的人类LRH-1
4. The role of feeding regimens in regulating metabolism of broiler breeders: hepatic lipid metabolism, plasma hormones and metabolites [C] . M. de Beer, R. W. Rosebrough, B.A. Russell, International Symposium on Energy and Protein Metabolism and Nutrition . 2007

机译：喂养方案在调节肉鸡育种者的代谢中的作用：肝脂代谢，血浆激素和代谢物
5. LRH-1 Signaling and Control of Liver Intermediary Metabolism: Impact on Nonalcoholic Fatty Liver Disease [D] . Silva, Vera Mónica Lemos da. 2018

机译：LRH-1肝脏中间代谢的信号和控制：对非酒精性脂肪肝病的影响
6. Genome-wide analysis of hepatic LRH-1 reveals a promoter binding preference and suggests a role in regulating genes of lipid metabolism in concert with FXR [O] . Hansook Kim Chong, Jacob Biesinger, Young-Kyo Seo, 2012

机译：肝LRH-1的全基因组分析揭示了启动子结合偏好并暗示了与FXR协同调节脂质代谢基因的作用
7. SUMOylation Places LRH-1 in PROXimity to Lipid Metabolism [O] . Priest Christina, Tontonoz Peter 2014

机译：SUMOylation使LRH-1接近脂质代谢

SUMOylation places LRH-1 in PROXimity to lipid metabolism

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