Obesity and FTO: Changing focus at a complex locus

TungY.C.L.; YeoG.S.H.; ORahillyS.; CollA.P.

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Obesity and FTO: Changing focus at a complex locus

机译：肥胖与FTO：将焦点转移到复杂的地方

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The fat mass and obesity-associated (FTO) gene was placed center stage when common intronic variants within the gene were robustly associated with human obesity. Murine models of perturbed Fto expression have shown effects on body weight and composition. However, a clear understanding of the link between FTO intronic variants and FTO activity has remained elusive. Two recent reports now indicate that obesity-associated SNPs appear functionally connected not with FTO but with two neighboring genes: IRX3 and RPGRIP1L. Here, we review these new findings and consider the implications for future analysis of GWAS hits.

机译：当基因中常见的内含子变异与人类肥胖密切相关时，脂肪量和肥胖相关（FTO）基因就处于中心位置。扰动的Fto表达的小鼠模型已显示出对体重和组成的影响。但是，对FTO内含子变体与FTO活性之间的联系的清晰了解仍然难以捉摸。现在有两个最新的报道表明，肥胖相关的SNP似乎在功能上与FTO无关，但与两个邻近的基因IRX3和RPGRIP1L相关。在这里，我们回顾了这些新发现，并考虑了对GWAS命中的未来分析的意义。

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《Cell metabolism》 |2014年第5期|共9页
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TungY.C.L.; YeoG.S.H.; ORahillyS.; CollA.P.;
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中图分类内分泌腺疾病及代谢病;
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1. Obesity and FTO: Changing focus at a complex locus [J] . TungY.C.L., YeoG.S.H., ORahillyS., Cell metabolism . 2014,第5期

机译：肥胖与FTO：将焦点转移到复杂的地方
2. Association between Common Variation at the FTO Locus and Changes in Body Mass Index from Infancy to Late Childhood: The Complex Nature of Genetic Association through Growth and Development [J] . Ulla Sovio, Dennis O. Mook-Kanamori, Nicole M. Warrington, PLoS Genetics . 2011,第2期

机译：FTO基因座的共同变异与从婴儿期到儿童期的体重指数变化之间的关联：通过生长和发育的遗传关联的复杂性
3. Association between Common Variation at the FTO Locus and Changes in Body Mass Index from Infancy to Late Childhood: The Complex Nature of Genetic Association through Growth and Development [J] . Ulla Sovio, Dennis O. Mook-Kanamori, Nicole M. Warrington, PLoS Genetics . 2011,第2期

机译： FTO 基因座的共同变异与从婴儿期到儿童期的体重指数变化之间的关联：通过生长和发育的遗传关联的复杂性
4. Novel, Focused Optoacoustic Transducers for Accurate Monitoring ofTotal Hemoglobin Concentration and Oxyhemoglobin Saturation:Pre-clinical and Clinical Tests [C] . Emanuel Sarchen, Irina Petrova, Yuriy Petrov, Conference on Photons Plus Ultrasound: Imaging and Sensing . 2010

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5. Changes in Quality of Emotional Processing in Trauma Narratives as a Predictor of Outcome in Emotion Focused Therapy for Complex Trauma. [D] . Khayyat-Abuaita, Ula. 2016

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6. Association between Common Variation at the FTO Locus and Changes in Body Mass Index from Infancy to Late Childhood: The Complex Nature of Genetic Association through Growth and Development [O] . Ulla Sovio, Dennis O. Mook-Kanamori, Nicole M. Warrington, 2011

机译：FTO基因座的共同变异与从婴儿期到儿童期的体重指数变化之间的关联：通过生长和发育的遗传关联的复杂性
7. Obesity and FTO: changing focus at a complex locus [O] . Tung Yi-Chun Loraine, Yeo Giles See, ORahilly Stephen, 2014

机译：肥胖与FTO：将焦点转移到复杂的地方

Obesity and FTO: Changing focus at a complex locus

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