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NAD(+) Metabolism and the Control of Energy Homeostasis: A Balancing Act between Mitochondria and the Nucleus

机译:NAD(+)代谢和能量稳态的控制:线粒体和细胞核之间的平衡行为。

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摘要

NAD(+) has emerged as a vital cofactor that can rewire metabolism, activate sirtuins, and maintain mitochondrial fitness through mechanisms such as the mitochondrial unfolded protein response. This improved understanding of NAD(+) metabolism revived interest in NAD(+)-boosting strategies to manage a wide spectrum of diseases, ranging from diabetes to cancer. In this review, we summarize how NAD(+) metabolism links energy status with adaptive cellular and organismal responses and how this knowledge can be therapeutically exploited.
机译:NAD(+)已成为一种重要的辅助因子,可以通过诸如线粒体未折叠的蛋白质反应等机制重新连接新陈代谢,激活sirtuins并维持线粒体适应性。对NAD(+)代谢的这种更好的理解重新激发了人们对NAD(+)增强策略的兴趣,以管理从糖尿病到癌症的各种疾病。在这篇综述中,我们总结了NAD(+)代谢如何将能量状态与适应性细胞和机体反应联系起来,以及如何通过治疗利用这一知识。

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