Silencing metabolic disorders by novel SIRT1 activators.

Sakamoto K

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Silencing metabolic disorders by novel SIRT1 activators.

机译：通过新型SIRT1激活剂沉默代谢紊乱。

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SIRT1, a NAD(+)-dependent protein deacetylase that regulates transcription factors involved in key cellular processes, has been implicated as a mediator of the beneficial effects of calorie restriction. In a recent issue of Nature, Milne et al. (2007) describe novel potent activators of SIRT1, whose administration to insulin-resistant animals improves glucose homeostasis.

机译：SIRT1是一种NAD（+）依赖性蛋白脱乙酰基酶，它调节关键细胞过程中涉及的转录因子，已被认为是热量限制的有益作用的介质。在最近出版的《自然》杂志中，米尔恩等人。（2007年）描述了SIRT1的新型有效激活剂，其对胰岛素抵抗动物的给药可改善葡萄糖体内稳态。

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《Cell metabolism》 |2008年第1期|共2页
作者
Sakamoto K;
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正文语种 eng
中图分类细胞生物学;
关键词
novel; Metabolic Diseases; cal; Cellular biology; 代谢疾病;

机译：novel;Metabolic Diseases;cal;Cellular biology;代谢疾病;

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专利

1. Silencing metabolic disorders by novel SIRT1 activators. [J] . Sakamoto K Cell metabolism . 2008,第1期

机译：通过新型SIRT1激活剂沉默代谢紊乱。
2. Biochemical effects of SIRT1 activators. [J] . Baur JA Biochimica et biophysica acta: BBA: International journal of biochemistry, biophysics and molecular biololgy. Proteins and Proteomics . 2010,第8期

机译：SIRT1激活剂的生化作用。
3. Discovery of oxazolo(4,5-b)pyridines and related heterocyclic analogs as novel SIRT1 activators. [J] . Bemis JE, Vu CB, Xie R, Bioorganic and Medicinal Chemistry Letters . 2009,第8期

机译：恶唑（4,5-b）吡啶和相关的杂环类似物作为新型SIRT1激活剂的发现。
4. C-Jun N-terminal Kinase Gene Silencing to Stimulate Elastic Matrix Regenerative Repair in a Proteolytic Disorders [C] . Daniel Ortiz, Andrew Camardo, Anand Ramamurthi Society for Biomaterials annual meeting and exposition . 2018

机译：C军N末端激酶基因沉默，以刺激蛋白水解紊乱的弹性基质再生修复。
5. The Impacts of Sleep Deprivation and Sleep Disorders on the Prevalence and Adverse Consequences of Metabolic Syndrome/Metabolic Risk Factors in United States Adults [D] . Mowatt, Giovani A. 2018

机译：睡眠剥夺和睡眠障碍对美国成年人代谢综合征/代谢危险因素的患病率和不良后果的影响
6. PPARα and Sirt1 Mediate Erythropoietin Action in Increasing Metabolic Activity and Browning of White Adipocytes to Protect Against Obesity and Metabolic Disorders [O] . Li Wang, Ruifeng Teng, Lijun Di, 2013

机译：PPARα和Sirt1介导促红细胞生成素作用以增加白色脂肪细胞的代谢活性和褐变从而预防肥胖和代谢紊乱。
7. Silencing metabolic disorders by novel SIRT1 activators [O] . Sakamoto, Kei 2008

机译：通过新型SIRT1激活剂沉默代谢紊乱

Silencing metabolic disorders by novel SIRT1 activators.

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