Fasting-induced hypothermia and reduced energy production in mice lacking acetyl-CoA synthetase 2.

Sakakibara I; Fujino T; Ishii M

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Fasting-induced hypothermia and reduced energy production in mice lacking acetyl-CoA synthetase 2.

机译：空腹诱导的体温过低和缺乏乙酰辅酶A合成酶2的小鼠的能量产生减少。

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Acetate is activated to acetyl-CoA by acetyl-CoA synthetase 2 (AceCS2), a mitochondrial enzyme. Here, we report that the activation of acetate by AceCS2 has a specific and unique role in thermogenesis during fasting. In the skeletal muscle of fasted AceCS2(-/-) mice, ATP levels were reduced by 50% compared to AceCS2(+/+) mice. Fasted AceCS2(-/-) mice were significantly hypothermic and had reduced exercise capacity. Furthermore, when fed a low-carbohydrate diet, 4-week-old weaned AceCS2(-/-) mice also exhibited hypothermia accompanied by sustained hypoglycemia that led to a 50% mortality. Therefore, AceCS2 plays a significant role in acetate oxidation needed to generate ATP and heat. Furthermore, AceCS2(-/-) mice exhibited increased oxygen consumption and reduced weight gain on a low-carbohydrate diet. Our findings demonstrate that activation of acetate by AceCS2 plays a pivotal role in thermogenesis, especially under low-glucose or ketogenic conditions, and is crucially required for survival.

机译：乙酸盐通过线粒体酶乙酰辅酶A合成酶2（AceCS2）活化为乙酰辅酶A。在这里，我们报告说，AceCS2醋酸盐的激活在禁食期间生热中具有特定而独特的作用。在禁食的AceCS2（-/-）小鼠的骨骼肌中，与AceCS2（+ / +）小鼠相比，ATP水平降低了50％。禁食的AceCS2（-/-）小鼠明显体温过低，运动能力降低。此外，当喂食低碳水化合物饮食时，4周龄断奶的AceCS2（-/-）小鼠也表现出体温过低，伴有持续的低血糖症，导致50％的死亡率。因此，AceCS2在产生ATP和热量所需的乙酸盐氧化中起重要作用。此外，AceCS2（-/-）小鼠在低碳水化合物饮食中表现出增加的耗氧量和减少的体重增加。我们的发现表明，AceCS2激活乙酸盐在生热中起着关键作用，尤其是在低葡萄糖或生酮条件下，并且是生存的关键。

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《Cell metabolism》 |2009年第2期|共12页
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Sakakibara I; Fujino T; Ishii M;
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中图分类细胞生物学;
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1. Fasting-induced hypothermia and reduced energy production in mice lacking acetyl-CoA synthetase 2. [J] . Sakakibara I, Fujino T, Ishii M Cell metabolism . 2009,第2期

机译：空腹诱导的体温过低和缺乏乙酰辅酶A合成酶2的小鼠的能量产生减少。
2. Continuous fat oxidation in acetyl-CoA carboxylase 2 knockout mice increases total energy expenditure, reduces fat mass, and improves insulin sensitivity [J] . Cheol Soo Choi, David B. Savage, Lutfi Abu-Elheiga, Proceedings of the National Academy of Sciences of the United States of America . 2007,第42期

机译：乙酰辅酶A羧化酶2基因敲除小鼠中的持续脂肪氧化会增加总能量消耗，减少脂肪量，并改善胰岛素敏感性
3. Mutant mice lacking acetyl-CoA carboxylase 1 are embryonically lethal [J] . Abu-Elheiga L, Matzuk MM, Kordari P, Proceedings of the National Academy of Sciences of the United States of America . 2005,第34期

机译：缺乏乙酰辅酶A羧化酶1的突变小鼠胚胎致死
4. Teamwork plus Technology Equals Reduced Emissions, Reduced Energy Usage, and Improved Productivity for an Oil Production Facility [C] . Garth Booker, James Robinson Twenty-Fifth National Industrial Energy Technology Conference; May 13-16, 2003; Houston, Texas . 2003

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6. Maternal Obesity Reduces Milk Lipid Production in Lactating Mice by Inhibiting Acetyl-CoA Carboxylase and Impairing Fatty Acid Synthesis [O] . Jessica L. Saben, Elise S. Bales, Matthew R. Jackman, -1

机译：母体肥胖通过抑制乙酰辅酶A羧化酶和损害脂肪酸合成来减少哺乳小鼠的乳脂产生
7. Fasting-Induced Hypothermia and Reduced Energy Production in Mice Lacking Acetyl-CoA Synthetase 2 [O] . Sakakibara Iori, Fujino Takahiro, Ishii Makoto, 2009

机译：空腹诱导的体温过低和缺乏乙酰辅酶A合成酶2的小鼠的能量产生减少。

Fasting-induced hypothermia and reduced energy production in mice lacking acetyl-CoA synthetase 2.

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