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首页> 外文期刊>Cell metabolism >Histone methyl transferases and demethylases; can they link metabolism and transcription?
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Histone methyl transferases and demethylases; can they link metabolism and transcription?

机译：组蛋白甲基转移酶和去甲基酶;它们可以将新陈代谢和转录联系起来吗？

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摘要

Heritable changes to the transcriptome that are independent to changes in the genome are defined as epigenetics. DNA methylation and posttranslational modifications of histones, such as acetylation/deacetylation and methylation/demethylation of lysine residues, underlie these epigenetic phenomena, which impact on many physiological processes. This perspective focuses on the emerging biology of histone methylation and demethylation, highlighting how these reactions depend on metabolic coenzymes like S-adenosylmethionine, flavin adenine dinucleotide, and alpha-ketoglutarate. Furthermore, we illustrate that methyltranferases and demethylases affect many metabolic pathways. Despite the preliminary evidence that methyltranferases and demethylases could link metabolic signals to chromatin and alter transcription, further research is indispensable to consolidate these enticing observations.
机译：独立于基因组变化的转录组的遗传变化被定义为表观遗传学。这些表观遗传现象构成了DNA甲基化和组蛋白的翻译后修饰，例如赖氨酸残基的乙酰化/脱乙酰化和甲基化/脱甲基，影响了许多生理过程。该观点着眼于组蛋白甲基化和去甲基化的新兴生物学，强调了这些反应如何依赖于代谢辅酶，如S-腺苷甲硫氨酸，黄素腺嘌呤二核苷酸和α-酮戊二酸。此外，我们说明了甲基转移酶和脱甲基酶影响许多代谢途径。尽管有初步证据表明甲基转移酶和脱甲基酶可以将代谢信号与染色质联系起来并改变转录，但进一步的研究对于巩固这些诱人的观察是必不可少的。

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