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Protein-inspired multilayer nanofilms:science,technology and medicine

机译：蛋白质启发的多层纳米膜：科学，技术和医学

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The field of polypeptide multilayer nanofilm research flourishes where study of protein structure and function shares a border with development of polyelectrolyte multilayers.The soil is fertile for creative input and promises a harvest of interesting results:the structure of a film can be predetermined on a layer-by-layer (LBL)basis,a huge variety of polypeptide sequences can be realized in large quantities by modern methods of synthesis,and the fabrication process is environmentally benign.In electrostatic LBL assembly,multilayer film assembly is driven primarily by coulombic interactions,but hydrophobic interactions and hydrogen bonds also contribute to film formation and stability,the amount depending on polypeptide design.Most peptides suitable for LBL assembly form films with a large percentage of beta-sheet at neutral pH;it would appear that beta-sheet is favored over alpha-helix in this context by the contribution to entropy of the number of ways of forming a beta-sheet from a single polypeptide chain.Film thickness and roughness depend rather substantially on amino acid composition.Promising applications of the polypeptide multilayer film platform technology include coatings for medical implant devices,scaffolds for tissue engineering,coatings for targeted drug delivery,artificial cells for oxygen therapeutics,and artificial viruses for immunization.In each case peptide structure is tailored to the application.Here we summarize recent results of experimental studies and computational work from our laboratory,showing how the study of protein structure has inspired the design of polypeptide films and pointing out new opportunities for technology development.This work also provides a brief introduction to polypeptide structure and multilayer films.
机译：多肽多层纳米薄膜的研究领域蓬勃发展，其中蛋白质结构和功能的研究与聚电解质多层薄膜的发展有共同的边界。土壤肥沃，富有创意，可以收获有趣的成果：薄膜的结构可以预先确定在一层上层（LBL）的基础上，现代合成方法可实现大量多肽序列的大量合成，且制造过程对环境无害。在静电LBL组装中，多层膜组装主要由库仑相互作用驱动，但大多数适合于LBL组装的肽形成的膜在中性pH值下具有很大的β-折叠膜，因此似乎倾向于使用β-折叠。在这种情况下，由α-螺旋形成的α-螺旋比由α形成螺旋的β-折叠方式的数量对熵的贡献大多肽的厚度和粗糙度在很大程度上取决于氨基酸组成。多肽多层膜平台技术的有前途的应用包括用于医疗植入设备的涂层，用于组织工程的支架，用于靶向药物递送的涂层，用于氧疗法的人造细胞以及在每种情况下，都根据应用情况量身定制肽结构。在这里，我们总结了实验室的实验研究和计算工作的最新结果，展示了蛋白质结构的研究如何激发多肽膜的设计并指出了新的机遇这项工作还简要介绍了多肽的结构和多层膜。

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