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首页> 外文期刊>Nanomedicine: Nanotechnology, Biology and Medicine >Reknitting the injured spinal cord by self-assembling peptide nanofiber scaffold
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Reknitting the injured spinal cord by self-assembling peptide nanofiber scaffold

机译：通过自组装肽纳米纤维支架重新编织受伤的脊髓

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In traumatic spinal cord injury,loss of neurological function is due to the inability of damaged axons to regenerate across large,cystic cavities.It has recently been demonstrated that a self-assembled nanofiber scaffold(SAPNS)could repair the injured optical pathway and restore visual function.To demonstrate the possibility of using it to repair spinal cord injury,transplanted neural progenitor cells and Schwann cells were isolated from green fluorescent protein-transgenic rats,cultured within SAPNS,and then transplanted into the transected dorsal column of spinal cord of rats.Here we report the use of SAPNS to bridge the injured spinal cord of rats,demonstrating robust migration of host cells,growth of blood vessels,and axons into the scaffolds,indicating that SAPNS provides a true three-dimensional environment for the migration of living cells.
机译：在创伤性脊髓损伤中，神经功能丧失是由于受损的轴突无法跨大的囊性腔再生。最近已证明，自组装的纳米纤维支架（SAPNS）可以修复受损的光路并恢复视觉为了证明其可用于修复脊髓损伤的可能性，从绿色荧光蛋白转基因大鼠中分离出移植的神经祖细胞和雪旺氏细胞，在SAPNS中培养，然后移植到大鼠脊髓横断背柱中。在这里，我们报道了SAPNS用于桥接大鼠受伤的脊髓，证明宿主细胞的强劲迁移，血管生长和轴突进入支架的过程，这表明SAPNS为活细胞的迁移提供了真实的三维环境。

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