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首页> 外文期刊>Cell motility and the cytoskeleton >Elastic extension and jump of the flagellar nexin links: A theoretical mechanical cycle.
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Elastic extension and jump of the flagellar nexin links: A theoretical mechanical cycle.

机译：鞭毛神经连接的弹性延伸和跳跃：理论上的机械循环。

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The functions of the nexin links of a flagellar axoneme have not been clearly demonstrated. Taking into account both the elastic (Hookean) characteristics and the possible jump of the nexin links, we calculated the sliding to bending conversion of a theoretical model in a tip-ward direction step by step, according to the essential principles proposed by the geometric clutch hypothesis [Lindemann, 1994: J Theoret Biol 168:175-189]: the activity of the dynein arms depends on the transverse forces induced by the axonemal curvature. In our calculations, however, the transverse forces that are involved in the regulation of the activities of the dynein arms were due to the extension of the nexin links located upstream of a given abscissa. This allowed us to define a bent segment as the axonemal portion at whose proximal and distal ends the nexin links were relaxed, and as fully extended as possible, respectively. The model creates an apparent disorder in the orientation of the nexin links as already observed [Bozkurt and Wooley, 1993: Cell Motil Cytoskeleton 24:109-118; Wooley, 1997: J Cell Sci 110:85-94]. We propose that the nexin links are involved in a mechanical cycle, whose 3 stages are (1) rapid extension, (2) slow relaxation, and (3) stand-by. The rapid extension is compatible with the mechanical interactions between the nexin links and the inner dynein arms with which they form the dynein regulatory complex. This was correlated with the oscillating properties of the nexin links along the axoneme that allow them to be one of the regulatory elements of the local ATPase activity of the dynein arms. Copyright 2001 Wiley-Liss, Inc.
机译：鞭毛轴索蛋白的nexin链接的功能尚未明确证明。考虑到弹性（Hookean）特性和nexin链接的可能跳动，我们根据几何离合器提出的基本原理，逐步计算了理论模型在尖端方向上的滑移到弯曲转换假说[Lindemann，1994：J Theoret Biol 168：175-189]：动力蛋白臂的活性取决于由轴突弯曲引起的横向力。然而，在我们的计算中，参与调节动力蛋白臂活动的横向力是由于位于给定横坐标上游的神经连结的延伸所致。这使我们可以将弯曲段定义为轴突部分，在该轴突部分的近端和远端，神经连接被放松，并分别尽可能地充分伸展。如已经观察到的，该模型在神经素连接的方向上产生了明显的紊乱[Bozkurt和Wooley，1993：Cell Motil Cytoskeleton 24：109-118; Prof.Natl.Acad。 Wooley，1997：J Cell Sci 110：85-94]。我们建议，nexin链接涉及一个机械周期，其3个阶段是（1）快速扩展，（2）缓慢松弛和（3）待机。快速延伸与nexin链与内部dynein臂之间的机械相互作用兼容，它们之间形成了dynein调节复合物。这与沿轴突的神经素连接的振荡特性相关，该连接蛋白使它们成为动力蛋白臂局部ATPase活性的调控元件之一。版权所有2001 Wiley-Liss，Inc.

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