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首页> 外文期刊>Cell motility and the cytoskeleton >Polar ejection forces are operative in crane-fly spermatocytes, but their action is limited to the spindle periphery.
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Polar ejection forces are operative in crane-fly spermatocytes, but their action is limited to the spindle periphery.

机译：极顶射力在鹤蝇精细胞中起作用，但它们的作用仅限于纺锤体外围。

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摘要

Laser microsurgery was employed to reveal kinetochore-independent forces acting on chromosome arms in crane-fly spermatocytes. When a portion of an arm situated along the interpolar axis between the equator and a pole was cut off, the resultant acentric fragment was transported poleward and outward into the peripheral domain of the spindle. If the fragment was generated well in advance of the onset of anaphase, then at the spindle periphery, it changed direction and moved away from the pole and back toward the equator. That domain-specific movement-poleward in the central spindle and away from the pole at the spindle periphery-not only provides the first evidence for polar ejection forces acting on acentric fragments in a meiotic system, but it is the first example of kinetochore-independent forces in both directions at the same stage of division. Sniglets generated by laser pulses directed at specific sites in the spindle revealed that the mechanism underlying ejection forces was specific to chromosomes. At anaphase onset, polar ejection forces ceased, and pole-directed forces took over. At that time, chromosome fragments that had been ejected to the equator moved poleward again, providing clear evidence for kinetochore-independent forces on chromosome arms during anaphase. Copyright 2002 Wiley-Liss, Inc.
机译：激光显微手术被用来揭示动鹤独立力作用于鹤蝇精细胞的染色体臂上。当沿着赤道和极之间的极间轴的一部分臂被切掉时，所得的无心碎片被极向和向外传输到心轴的外围区域。如果碎片是在后期开始之前很好地产生的，则在纺锤体外围，它会改变方向并远离极点并移回到赤道。这种特定于域的运动（在中心纺锤中向极点运动，并远离纺锤体外围的极点）不仅为极性减射力作用在减数分裂系统中的无心碎片上提供了第一个证据，而且是动粒独立的第一个例子在分裂的同一阶段在两个方向上的力量。激光脉冲直接作用于纺锤体中特定部位而产生的小片段表明，弹射力的潜在机制是染色体特有的。在后期开始时，极地弹射力停止，极向力接管。当时，被弹出到赤道的染色体碎片再次向极移，为后期阶段染色体臂上独立于动粒的力提供了清晰的证据。版权所有2002 Wiley-Liss，Inc.

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