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Lab-on-a-chip technology: impacting non-invasive prenatal diagnostics (NIPD) through miniaturisation

机译:芯片实验室技术:通过小型化影响非侵入性产前诊断(NIPD)

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摘要

This paper aims to provide a concise review of non-invasive prenatal diagnostics (NIPD) to the lab-on-a-chip and microfluidics community. Having a market of over one billion dollars to explore and a plethora of applications, NIPD requires greater attention from microfluidics researchers. In this review, a complete overview of conventional diagnostic procedures including invasive as well as non-invasive (fetal cells and cell-free fetal DNA) types are discussed. Special focus is given to reviewing the recent and past microfluidic approaches to NIPD, as well as various commercial entities in NIPD. This review concludes with future challenges and ethical considerations of the field.
机译:本文旨在为芯片实验室和微流体领域的非侵入性产前诊断(NIPD)提供简要的综述。 NIPD的市场规模超过10亿美元,其应用众多,因此需要微流体研究人员给予更大的关注。在这篇综述中,讨论了常规诊断程序的完整概述,包括侵入性和非侵入性(胎儿细胞和无细胞胎儿DNA)类型。特别着重于回顾NIPD的最新和过去的微流体方法,以及NIPD中的各种商业实体。本文以该领域的未来挑战和道德考量作为总结。

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