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首页> 外文期刊>Laboratory Animal Science >OXYGEN SATURATION MONITORING IN EXPERIMENTAL SURGERY - A COMPARISON OF PULSE OXIMETRY AND ARTERIAL BLOOD GAS MEASUREMENT
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OXYGEN SATURATION MONITORING IN EXPERIMENTAL SURGERY - A COMPARISON OF PULSE OXIMETRY AND ARTERIAL BLOOD GAS MEASUREMENT

机译：实验手术中的氧气饱和度监测-脉搏血氧饱和度和动脉血气测量的比较

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摘要

Experimental surgery in animal models often requires prolonged periods of general anesthesia. Animals undergoing these procedures may have difficulty maintaining normal ventilation and oxygenation and therefore may require physiologic monitoring and endotracheal intubation to avoid hypoxia that could adversely affect the results of the investigation. Monitoring has traditionally included measurements of PaO2, PCO2, pH, and oxygen saturation calculated from arterial blood. Endotracheal intubation and placement of arterial catheters necessary for the intraoperative collection of specimens for blood gas analysis are labor-intensive and time consuming. In this study, rats undergoing thoracic laminectomy as part of a study on spinal cord injury were monitored by noninvasive pulse oximetry, with a reflectance transducer placed on the skin/fur of the neck overlying the cervical carotid artery. Comparison of these data with intermittent arterial blood gas measurements in the same animals indicated >90% concordance with the pulse oximetry values. We also determined the fraction of inspired oxygen (FiO(2)) that, delivered via facemask, can achieve at least the minimal normal oxygen saturation (SaO(2)) of 90%. These findings suggest that physiologic monitoring during experimental rodent surgery can be substantially simplified by pulse oximetry and by delivery of oxygen via facemask, eliminating the need for arterial blood gas determinations or endotracheal intubation.
机译：动物模型中的实验性手术通常需要长时间的全身麻醉。接受这些程序的动物可能难以维持正常的通气和充氧，因此可能需要进行生理监测和气管插管，以避免可能对研究结果产生不利影响的缺氧。传统上，监测包括从动脉血中计算出的PaO2，PCO2，pH和氧饱和度的测量值。术中采集血气分析标本所必需的气管内插管和动脉导管的放置是劳动密集型且耗时的。在这项研究中，作为非脊髓损伤研究的一部分，对接受胸椎切除术的大鼠进行了无创脉搏血氧饱和度监测，并在颈部皮肤/皮毛上覆盖颈颈动脉的位置放置了反射传感器。这些数据与相同动物中间歇性动脉血气测量值的比较表明，与脉搏血氧饱和度测量值的一致性> 90％。我们还确定了通过面罩输送的吸入氧气（FiO（2））至少可以达到90％的最小正常氧气饱和度（SaO（2））。这些发现表明，通过脉搏血氧仪和通过面罩输送氧气可以大大简化实验性啮齿动物手术过程中的生理监测，从而无需进行动脉血气测定或气管插管。

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