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首页> 外文期刊>Laboratory Animal Science >QUANTITATIVE ANALYSIS OF ABNORMAL SPONTANEOUS BEHAVIOR AND CLINICAL ASSESSMENT OF THE STARGAZER RAT
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QUANTITATIVE ANALYSIS OF ABNORMAL SPONTANEOUS BEHAVIOR AND CLINICAL ASSESSMENT OF THE STARGAZER RAT

机译：STARGAZER大鼠异常自发行为的定量分析及临床评价。

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A new mutant derived from the Zucker rat strain called stargazer (homozygous stg/stg) displays abnormal behavior that is characterized by pronounced arching of the neck (''stargazing''), rapid circling, and conspicuous hyperactivity. Results of serologic assays performed by two independent diagnostic laboratories have indicated that the abnormal behavior in the stargazer is not the result of a viral or bacterial infection, In this report, different groups of stargazer rats and their normal-behaving littermates (heterozygous stg/+) were assessed with regard to spontaneous behaviors, heart rate, blood pressure, and plasma biochemical profiles. Besides frequent stargazing, the predominant behavioral feature of the stargazers was extreme hyperactivity; they had sevenfold greater activity than the normal littermates (P < 0.05), expressed in the form of rapid ambulation and tail-chasing, The stargazers had significantly greater daily calorie and water consumption, despite being significantly smaller in body weight than the littermates (P < 0.05 for all). However, urine output was not different between the two groups. Heart rate and blood pressure also were not different, Stargazers had significantly lower total triglycerides concentration and lower aminotransferase activity than littermates (P < 0.05 for both), a finding probably related to their smaller body size, It is concluded that stargazer rats are extremely hyperactive but normotensive; heterozygous littermates are behaviorally normal, despite being carriers of the stg gene; and routine diagnostic blood testing revealed no important differences between the stargazers and their unaffected littermates.
机译：源自祖克（Zucker）大鼠品系的新突变体称为“凝视星”（纯合子stg / stg），表现出异常行为，其特征为明显的颈部弓形（“凝视”），快速盘旋和明显的过度活跃。由两个独立的诊断实验室进行的血清学分析结果表明，占星者的异常行为不是病毒或细菌感染的结果。在本报告中，不同组的占星者大鼠及其行为正常的同窝仔（杂合子stg / +评估了有关自发行为，心率，血压和血浆生化特征的信息。除了经常观星，观星者的主要行为特征是过度活跃。他们的活动能力比正常同窝仔高7倍（P <0.05），表现为快速下床和追尾。占星者的每日卡路里和水消耗明显高于同窝仔，尽管体重明显低于同窝仔（P均<0.05）。但是，两组的尿量没有差异。心率和血压也没有差异，观星者的总甘油三酸酯浓度和氨基转移酶活性均显着低于同窝仔（P均<0.05），这一发现可能与其体型较小有关。但血压正常;尽管是stg基因的携带者，杂合子同窝行为仍是正常的。常规诊断性血液测试显示，观星者与其未受影响的同窝仔之间没有重要差异。

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