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首页> 外文期刊>Laboratory Animal Science >Humoral immunity and protection of mice challenged with homotypic or heterotypic parvovirus
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Humoral immunity and protection of mice challenged with homotypic or heterotypic parvovirus

机译：同型或异型细小病毒攻击的小鼠的体液免疫和保护

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Infant mice without maternal antibody or antibody to minute virus of mice (MVM) or mouse parvovirus (MPV) and young adult mice given normal mouse serum or antibody to MVM or MPV were challenged with homotypic or heterotypic virus. In situ hybridization with target tissues was the indicator of infection. Humoral immunity failed to confer protection against acute heterotypic parvovirus infection. In passive transfer studies, MPV DNA was observed occasionally in lymph nodes, intestine or the spleen ofMPV-challenged mice given homotypic antibody and kept for 6 or 28 days. Variable proportions of mice given MPV antibody and homotypic challenge had viral DNA in lymphoid tissues 56 days after virus inoculation. It is concluded that a mouse or colony that has sustained infection with MVM or MPV is probably fully susceptible to infection with the heterotypic virus.
机译：用同型或异型病毒攻击没有母源抗体或小鼠微小病毒抗体（MVM）或小鼠细小病毒（MPV）的婴儿小鼠和给予正常小鼠血清或MVM或MPV抗体的成年幼鼠。与靶组织的原位杂交是感染的指标。体液免疫未能赋予针对急性异型细小病毒感染的保护。在被动转移研究中，偶尔在接受同型抗体的MPV攻击小鼠的淋巴结，肠道或脾脏中观察到MPV DNA，并保持6或28天。接种病毒56天后，接受MPV抗体和同型攻击的小鼠中可变比例的淋巴组织中具有病毒DNA。结论是，受到MVM或MPV持续感染的小鼠或菌落可能完全易受异型病毒感染。

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